In the era of cut throat competition, especially in the automobile sector, the success of an organization resides in its ability to reply quickly to the wants of its customers. The customer needs must be attended with minimum manufacturing costs, and delivering better performance than the existing competitors in the market. Cost and Quality are two very important aspects to be globally competitive, to capture market share, to retain customers to be in business and to attain business excellence. Six Sigma is the powerful methodology to drive improvement initiatives and reduce cost of quality. Therefore, it is very much essential to know the relation between six sigma and cost of quality and its application in automobile industry. In the present times Six Sigma Methodologies are very famous and powerful tool and are widely used in the global industries.If the proposed Framework effectively implemented by Automobile industries then they will get the following benefits; reduction of defects, reduction in re-work, reduction in cycle time, increase in productivity, improved design, reduction in Cost of Quality, improved market share, customer satisfaction & delight.