Medicine is an ever-change science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. Integrative medicine combines the science and technology of traditional health care with safe and effective complementary therapies to provide comfort, healing and well-being. Advanced techniques in herbal extraction make them more effective and economical and attract more users. In our researches we used herbal medicine as integrative method in approach to intractable disease like: Diabetes type 2, Hepatitis B, Psoriasis, Infertility, rheumatoid arthritis, erectile dysfunction etc. These researches present the results of a three-year study of a clinical-based center for integrative medicine. Results show integrative treatment has an impressive effect in approach to intractable disease. We hope you will find this research paper useful as an up to date resource for information in the ever- expanding discipline of integrative medicine, and as a valuable tool for the education of your trainees and the care of your patients. It may change your view of disease and conventional medicine.