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The monograph presents the results of scientific and research work, providing for a balanced regulation of the rights and obligations of various environmental protection systems regarding the conservation of natural resources aimed at protecting nature as an environment-forming component of the natural environment, health conservation, as well as to ensure their multilateral use of medical ecology in rural and forest areas. The subject of the study was a set of theoretical, methodological, methodological and practical aspects of the development and sustainable management of the implementation of the concept of sustainable management of natural resources, forest sector in the organization and application of health-saving technologies.The practical significance of the research results consists in the fact that methodological tools, techniques and methods of accounting for the volume of environmental, agro-industrial forestry, their economic evaluation and performance indicators provide an opportunity for the formation of sustainable management of innovation systems of the cluster of medico-ecological systems, investment programs of health-saving technologies, create a basis for the regulation of effective environmental management.