Prologue.- Disparate Themes: Origins and Integration.- Fatty Acids, Mitochondria, and Signal Transduction: Integrated Control of Cell Proliferation, Injury, and Death.- to Part II.- Nutrient and Energy Metabolism in Cell Proliferation.- Fatty Acids and Growth Regulation.- Mitochondrial Function in Cell Growth and Death.- Metabolic Effects of Antiproliferative Agents.- Fatty Acids and Mitochondria, Cell Growth and Injury: Broader Implications.- Metabolism and Gene Expression in Liver Regeneration.- II Conclusions.- Fatty Acids, Ketone Bodies, and Brain Metabolism: Implications for Neuronal Function and Alzheimer Disease.- to Part III.- Energetics of Neuronal Activation.- Utilization of Oxidizable Substrates in Brain.- Astrocyte Metabolism and Astrocyte-Neuron Interaction.- Neuronal Energy Metabolism in Brain: Astrocyte as both Metabolic “Buffer” and Mediator of Neuronal Injury.- Pathogenesis of Alzheimer Disease: Metabolic Factors.- III Conclusions.- Epilogue.- Looking Back, Looking Ahead.