Progress made in the last 20 years clearly indicates that the cell surface is an extremely dynamic structure involved in fundamental processes such as cell motility, innervation, and cell adhesion. Of particular interest is the finding that, in several tissues, the cell surface is differen tiated at the intercellular region, thereby providing communicating chan nels between apposing cells. Although our actual knowledge of the precise structures and mecha in the complex process of intercellular communication is still nisms involved scanty, evidence has been presented that ions and molecules…mehr
Progress made in the last 20 years clearly indicates that the cell surface is an extremely dynamic structure involved in fundamental processes such as cell motility, innervation, and cell adhesion. Of particular interest is the finding that, in several tissues, the cell surface is differen tiated at the intercellular region, thereby providing communicating chan nels between apposing cells. Although our actual knowledge of the precise structures and mecha in the complex process of intercellular communication is still nisms involved scanty, evidence has been presented that ions and molecules diffuse from cell to cell, establishing a physiological continuum. Embryonic differentia tion, cell growth, neoplasia, electrical synchronization in nerve and mus cles, as well as immune response seem to be related to ceIl communication. In organizing this volume, it has been our intention to provide the reader with an actual review of the processes involved in intercellular communication in normal tissues as well as in neoplasia. We sincerely believe that the opinions and experiences described herein will be of help in establishing new perspectives for the future of this exciting new field of cell biology. We wish to thank all the colleagues who joined us in the organization of this volume, as well as Plenum Publishing Corporation for making its appearance possible.
1 Gap Junctions in Development.- 1. Introduction.- 2. Gap Junctions as Mediators of Cell Coupling.- 3. Formation of Gap Junctions.- 4. Gap Junctions in Development.- 5. Possible Roles of Gap Junctions.- 6. Conclusion.- References.- 2 Cell Contact Phenomena and Their Implication in Cell Communication.- 1. Introduction.- 2. A Theoretical Physical Approach to Cell Contact.- 3. Experimental Observations.- 4. Cell Surface Heterogeneity and Contact.- 5. Mechanisms of Cell Interactions over Long Distances.- 6. Contact and Junctions.- 7. Junctions and Cancer.- References.- 3 Junctional Permeability and Its Consequences.- 1. Introduction.- 2. Methods for Studying Junctional Permeability.- 3. Junctions Are Permeable to Small Molecules.- 4. Junctions Are Not Permeable to Macromolecules.- 5. The Extent and Rate of Junctional Transfer Is Quantitatively Important.- 6. Junctions in Vivo Are the Same as Junctions in Culture.- 7. Lack of Specificity of Junction Formation and Junctional Permeability.- 8. Consequences of Junctional Permeability.- References.- 4 Intercellular Communication in Heart Muscle.- 1. Morphological Considerations.- 2. Spread of Excitation in Heart Muscle.- 3. Intercellular Structures Involved in the Coupling Process in Adult Cardiac Muscle.- 4. The Permeability of the Intercellular Junctions.- 5. Sodium Pump as a Regulatory Mechanism of Intercellular Communication.- 6. The Importance of Intercellular Junctions in the Healing-Over Process.- 7. Intercellular Junctions and the Synchronization of Pacemaker Cells.- 8. Uncoupling of Pacemaker Cells during Synaptic Inhibition.- 9. Conclusion.- References.- 5 Protein Semiconduction: An Alternative Explanation of Electrical Coupling.- 1. Introduction.- 2. The Channel Hypothesis.- 3. The Passage of Substances across the Septum of the Lateral.- Giant Axon of the Crayfish.- 4. Summary.- References.- 6 Intercellular Communication and Cancer.- 1. Introduction.- 2. Coupling in Normal Cells.- 3. Metabolic Cooperation.- 4. Formation of Coupling Junctions.- 5. Coupling in Cancer Cells.- 6. The Structural Correlate of the "Permeable Cell Junction".- 7. The Function of Gap Junctions in Normal Inexcitable Cells.- 8. Gap Junctions and Cancer.- References.- 7 Cell Interactions in Neuroblastoma.- 1. Cell Interactions in Neuroblastoma.- 2. Neuroblastoma Interactions in Vitro.- 3. Neuroblastoma Interactions in Vivo.- 4. Conclusion.- References.- 8 Cell Communication in the Immune Response.- 1. Introduction.- 2. Cellular Elements of the Immune Response.- 3. Aspects of the Biology of the Macrophage.- 4. T- and B-Cell Collaboration in Immune Responses.- 5. Lymphocyte-Macrophage Interactions.- 6. Cell Communication in Lymphocytes.- References.- 9 Intercellular Communication in the Early Embryo.- 1. Introduction.- 2. Physiological Analysis of Junctional Communication.- 3. Junctional Communication in Embryos.- 4. Functional Aspects of Junctional Communication in the Amphibian Embryo.- 5. Conclusion.- References.
1 Gap Junctions in Development.- 1. Introduction.- 2. Gap Junctions as Mediators of Cell Coupling.- 3. Formation of Gap Junctions.- 4. Gap Junctions in Development.- 5. Possible Roles of Gap Junctions.- 6. Conclusion.- References.- 2 Cell Contact Phenomena and Their Implication in Cell Communication.- 1. Introduction.- 2. A Theoretical Physical Approach to Cell Contact.- 3. Experimental Observations.- 4. Cell Surface Heterogeneity and Contact.- 5. Mechanisms of Cell Interactions over Long Distances.- 6. Contact and Junctions.- 7. Junctions and Cancer.- References.- 3 Junctional Permeability and Its Consequences.- 1. Introduction.- 2. Methods for Studying Junctional Permeability.- 3. Junctions Are Permeable to Small Molecules.- 4. Junctions Are Not Permeable to Macromolecules.- 5. The Extent and Rate of Junctional Transfer Is Quantitatively Important.- 6. Junctions in Vivo Are the Same as Junctions in Culture.- 7. Lack of Specificity of Junction Formation and Junctional Permeability.- 8. Consequences of Junctional Permeability.- References.- 4 Intercellular Communication in Heart Muscle.- 1. Morphological Considerations.- 2. Spread of Excitation in Heart Muscle.- 3. Intercellular Structures Involved in the Coupling Process in Adult Cardiac Muscle.- 4. The Permeability of the Intercellular Junctions.- 5. Sodium Pump as a Regulatory Mechanism of Intercellular Communication.- 6. The Importance of Intercellular Junctions in the Healing-Over Process.- 7. Intercellular Junctions and the Synchronization of Pacemaker Cells.- 8. Uncoupling of Pacemaker Cells during Synaptic Inhibition.- 9. Conclusion.- References.- 5 Protein Semiconduction: An Alternative Explanation of Electrical Coupling.- 1. Introduction.- 2. The Channel Hypothesis.- 3. The Passage of Substances across the Septum of the Lateral.- Giant Axon of the Crayfish.- 4. Summary.- References.- 6 Intercellular Communication and Cancer.- 1. Introduction.- 2. Coupling in Normal Cells.- 3. Metabolic Cooperation.- 4. Formation of Coupling Junctions.- 5. Coupling in Cancer Cells.- 6. The Structural Correlate of the "Permeable Cell Junction".- 7. The Function of Gap Junctions in Normal Inexcitable Cells.- 8. Gap Junctions and Cancer.- References.- 7 Cell Interactions in Neuroblastoma.- 1. Cell Interactions in Neuroblastoma.- 2. Neuroblastoma Interactions in Vitro.- 3. Neuroblastoma Interactions in Vivo.- 4. Conclusion.- References.- 8 Cell Communication in the Immune Response.- 1. Introduction.- 2. Cellular Elements of the Immune Response.- 3. Aspects of the Biology of the Macrophage.- 4. T- and B-Cell Collaboration in Immune Responses.- 5. Lymphocyte-Macrophage Interactions.- 6. Cell Communication in Lymphocytes.- References.- 9 Intercellular Communication in the Early Embryo.- 1. Introduction.- 2. Physiological Analysis of Junctional Communication.- 3. Junctional Communication in Embryos.- 4. Functional Aspects of Junctional Communication in the Amphibian Embryo.- 5. Conclusion.- References.
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