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The interdental papilla is the most vital structure of dental esthetics. Loss of interdental papilla will lead to a combination of esthetic, phonetic and functional deformity. There are various interdisciplinary therapeutic strategies i.e., periodontal, orthodontic, restorative strategies been advocated for its management. Among them there are various surgical and nonsurgical periodontal therapies been proposed aiming at regeneration or augmentation of the lost interdental papilla. This textbook discusses complexly about the various therapeutic strategies been proposed till date.