Interferon-Gamma: A marker of tuberculosis mediated immune response - Hussain, Shahid; Afzal, Nadeem
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Background: Interferon gamma (IFN-¿), a cytokine produced by a variety of cells is involved in the immune response against M.tuberculosis. It activates the production of other cytokines & molecules that kill MTB. IFN-¿ also has diagnostic role in identification of active and latent TB. Objective: To determine the level of IFN-¿ in the blood of TB patients. Methods: 91 subjects were selected, including 54 active TB patients and 37 healthy controls. IFN-¿ conc. was determined in their blood by ELISA technique. Results: In TB patients, Mean+SD of IFN-¿ was 48.69+28.78 while it was 12.99+5.70 pg/ml in control group (p …mehr

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Produktbeschreibung
Background: Interferon gamma (IFN-¿), a cytokine produced by a variety of cells is involved in the immune response against M.tuberculosis. It activates the production of other cytokines & molecules that kill MTB. IFN-¿ also has diagnostic role in identification of active and latent TB. Objective: To determine the level of IFN-¿ in the blood of TB patients. Methods: 91 subjects were selected, including 54 active TB patients and 37 healthy controls. IFN-¿ conc. was determined in their blood by ELISA technique. Results: In TB patients, Mean+SD of IFN-¿ was 48.69+28.78 while it was 12.99+5.70 pg/ml in control group (p <0.001). Significant differences in the level of IFN-¿ were observed among confirmed TB patients, clinically diagnosed TB patients and the control group (Mean+SD 59.68+28.78, 36.85+24.76 and 12.99+5.70 pg/ml, respectively). Furthermore, a significant negative correlation was observed b/w conc. of IFN-¿ in TB patients and the duration of anti-tuberculosis therapy. Conclusion: IFN-¿ level was high in both clinically diagnosed and confirmed TB patients as compared to a control group. Measurement of IFN-¿ is helpful to diagnose active TB, but further research is required.
Autorenporträt
Shahid Hussain received M.Sc. (Hons.) soil science degree from the University of Agriculture, Faisalabad (Pakistan) in 2009. Now, he is a PhD scholar in the same institute. His reseach is mainly focused on micronutrient management for cereal crops and their biofortification with zinc.