Tareq Abu Saleh

Interleukin-1 Genetic polymorphisms in African ancestry

Prevalence and association with chronic periodontitis in the Xhosa population of South Africa

• Broschiertes Buch

Produktbeschreibung

Bacterial pathogens are the primary aetiologic
factors in periodontal disease. The disease process
is modified by several risk factors, including;
smoking, systemic diseases and genetic influences.
Host response to periodontal disease is a protective
as well as a destructive process and the role of pro-
inflammatory cytokines, notably interleukin-1 in
bone resorption and attachment loss has been
reported.
A specific polymorphism in the interleukin-1 gene
cluster is associated with severity of
periodontitis.
Studies designed to estimate the genetic risk for
periodontitis indicated that both smoking habits
and ethnicity are confounding factors.
The prevalence of periodontitis appears to vary
between populations with different genetic
backgrounds, and findings from one ethnic group may
not be extrapolated to other ethnic groups. Perusal
of the literature indicates that this is the first
study to evaluate the prevalence of the interleukin-
1 composite genotype and its association with
chronic periodontal disease in a population of
African ancestry. The study results might be useful
to interested researchers and students alike.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 116
• Englisch
• ISBN-13: 9783639142686
• ISBN-10: 3639142683
• Artikelnr.: 26334744

Autorenporträt

Dr Tareq Abu Saleh, MSc, MRD RCSEd, pursued postgraduate studies
in Oral Medicine and Periodontology at the University of the
Western Cape, South Africa, then completed the speciality exams
in periodontics at the Royal College of Surgeons of Edinburgh.
Works at private practice limited to periodontics and implant
dentistry in Jordan.