It is suggested that the stenosing effects of atherosclerosis may be offset by regression of the lesion, senescent dilatation of the arterial wall and by enlargement of anastomotic channels. Regression is slow and such inertia is attributed to: absence of cholesterol catabolic enzymes; disproportion of the ratio of LDLlHDL; physical inaccessibility of crystalline cholesterol; and relative absence of reticuloendothelial phagocytes. Moderate dilatation of the human coronary arterial wall with advancing age seems to compen sate for the inward encroachment of atherosclerosis on the lumen, hence…mehr
It is suggested that the stenosing effects of atherosclerosis may be offset by regression of the lesion, senescent dilatation of the arterial wall and by enlargement of anastomotic channels. Regression is slow and such inertia is attributed to: absence of cholesterol catabolic enzymes; disproportion of the ratio of LDLlHDL; physical inaccessibility of crystalline cholesterol; and relative absence of reticuloendothelial phagocytes. Moderate dilatation of the human coronary arterial wall with advancing age seems to compen sate for the inward encroachment of atherosclerosis on the lumen, hence the status quo ante may be preserved. Severe atrophy with gross dilatation (ectasia) leads to haemodynamic difficulties with slow circulation as a result of marked fall in perfusion pressure. Such overdilated ectatic coronary arteries are particularly liable to undergo thrombosis. References Adams, C. W. M. , and Bayliss, O. B. (1976a): Detection of macrophages in atherosclerotic lesions with cytoduome oxidase. Brit. J. Exp. Pathol. 57, 30 to 36. Adams, C. W. M. , and Bayliss, O. B. (1976b): Succinic dehydrogenase and cytochrome oxidase in arterial, venous and other smooth muscle. Atherosclerosis 23, 367 to 370. Adams, C. W. M. , Knox, J. , and Morgan, R. S. (1975a): The resorption rate of atheroma lipids in situ and implanted subcutaneously. Atherosclerosis 22, 79 to 90. Adams, C. W. M. , Morgan, R. S. , and Bayliss, o. B. (1973): No regression of atheroma over one year in rabbits previously fed a cholesterol or enriched diet. Atherosclerosis 18, 429 to 444.
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Abhandlungen der Rheinisch-Westfälischen Akademie der Wissenschaften
Begrüßung.- Geschäftsführender Direktor des Institutes für Arterioskleroseforschung an der Universität Münster.- Grußadressen.- Präsident der Rheinisch-Westfälischen Akademie der Wissenschaften.- Rektor der Westfälischen Wilhelms-Universität Münster.- Dekan des Fachbereichs Klinische Medizin der Westfälischen Wilhelms-Universität Münster.- Oberbürgermeister der Stadt Münster.- Vorsitzender des Vorstandes der Gesellschaft für Arterioskleroseforschung e. V. Münster.- Introducing Presentation.- Introducing Presentation.- Evaluation of Animal Models for the Study of the Pathogenesis of Atherosclerosis.- Evaluation of Epidemiology Concerning Prevention and Therapy of Atherosclerosis.- The Origin in Atherosclerotic Lesions of Extracellular Lipid and Debris and their Elimination during Regression.- Quantitative Studies of Atherosclerotic Plaque Size in Human Subjects.- Reversibility and Prevention.- The Reversibility of the Human Atherosclerotic Plaque.- Effect of a Diet Enriched in Polyunsaturated Fatty Acids on Hyperlipoproteinemia in Man.- Atherosclerosis, a Preventable Disease? Autopsy Evidence.- Epidemiological Research in Western Europe.- Platelets in Relation to Atherosclerosis.- Regression of Atherosclerosis.- Problems in Experimental Atherosclerosis.- Some Cellular and Metabolic Aspects of Regression of Atherosclerosis, and the Compensatory Effect of Senile Arterial Dilatation.- Prevention and Regression in Animal Models by Diet and Cholestyramine.- On the Effects of Cholestyramine on Regression of Arterial Lesions in Rhesus Monkeys and of Metformin in Preventing Arterial Lesions in Hypercholesterolemic Rabbits.- Stroke and Heart Attack Induced Experimentally by Thromboxane A2 in Rabbits and Effect of EG 626, a Thromboxane A2 Antagonist.-Prevention and Therapy of Induced Atherosclerosis in Rabbits and Monkeys Regardless of Serum Cholesterol Levels.- Regression of Advanced Atherosclerosis in Swine.- Follow up of Arterial Mural Transport in Model Experiments and the Possibilities of Influencing it.- Immunological Factors in Vascular Diseases.- Pathological Findings Following Immunization with Vascular Tissues.- Microtubules in Arterial Smooth Muscle Cells in Vivo and in Culture An Electron Microscope Study.- Arteriosclerosis of Rats Induced by Fat-Free Diet.- Vascular Smooth Muscle Cells in Culture after Experimental Diabetes.- Alteration of DNA Template Activity in Artery Wall Cells Induced by Risk Factors.- Drugs and Hormones.- Role of Vasoactive Agents and Hypertension in Accelerated Atherogenesis.- Biosynthesis and Degradation of Matrix Macromolecules of the Arterial Wall. Regulation by Drug Action.- Mortality in Longterm Survivors from Myocardial Infarction after D-Penicillamine Therapy.- Effect of Mesenchyme Suppressive Drugs on Sclerogenesis in Animal Models.- A Factor in Diabetic Serum Stimulating Proliferation of Arterial Medial Cell Culture.- Large Vessel Disease in Diabetics - A Specific Diabetic Angiopathy?.- Inhibitory Influence of Somatostatin (Growth-Hormone-Release-Inhibiting-Factor; SRIF) on Mesenchymal Cells of Rats.- Influence of Hormones on Arterial Smooth Muscle Cell Proliferation.- In Vitro Effects of Estrogen on Cyclic Nucleotides in the Arterial Wall.- Effect of Prednisolone and D-Penicillamine on Toxin and LDL Induced Proliferative Activity of ASMC of the Minipig.- Lipid Problems.- Serum Triglycerides and High Density Lipoprotein Cholesterol in Healthy Persons and in Coronary Patients without Increased Serum Cholesterol.- Intervention Results in High Risk Individuals of the CBHeart Project in The Netherlands.- Enzyme - Substrate - Product Interactions in the Metabolism and Accumulation of Lipids in the Arterial Wall.- Physicochemical Factors in the Distribution of Plasma Lipoprotein Subunits between the Plasma Lipoproteins and the Arterial Wall.- Some Aspects on the Mechanism of Plasma Triglyceride Hydrolysis.- Risk and Healing Factors.- Arteriography Changes after Partial Ileal Bypass.- Tobacco Smoke as a Risk Factor in the Etiology of Arteriosclerosis.- Stop Smoking Training in Patients with Coronary Heart Disease.- Rehabilitation after Myocardial Infarction.- Prevention of the Clinical Symptoms of Atherosclerosis by Sport.- Causes of Cardiovascular Mortality and Morbidity in a Longitudinal Epidemiological Study.- Secondary Prevention by Physical Exercise in Patients after Myocardial Infarction (A Controlled Study in Randomized Groups of Exercising and Non-Exercising Patients).- Coagulation and Arteriosclerosis.- Plasmatic Coagulation in the Pathogenesis of Arteriosclerosis.- Surface Charge Properties of Endothelium of the Aorta in Young and Old Animals.- Platelet Aggregation in Atherosclerosis and its Inhibition by Antiplatelet Drugs.- Concluding Remarks.- Animal Models.- Human Arteriosclerosis.
Begrüßung.- Geschäftsführender Direktor des Institutes für Arterioskleroseforschung an der Universität Münster.- Grußadressen.- Präsident der Rheinisch-Westfälischen Akademie der Wissenschaften.- Rektor der Westfälischen Wilhelms-Universität Münster.- Dekan des Fachbereichs Klinische Medizin der Westfälischen Wilhelms-Universität Münster.- Oberbürgermeister der Stadt Münster.- Vorsitzender des Vorstandes der Gesellschaft für Arterioskleroseforschung e. V. Münster.- Introducing Presentation.- Introducing Presentation.- Evaluation of Animal Models for the Study of the Pathogenesis of Atherosclerosis.- Evaluation of Epidemiology Concerning Prevention and Therapy of Atherosclerosis.- The Origin in Atherosclerotic Lesions of Extracellular Lipid and Debris and their Elimination during Regression.- Quantitative Studies of Atherosclerotic Plaque Size in Human Subjects.- Reversibility and Prevention.- The Reversibility of the Human Atherosclerotic Plaque.- Effect of a Diet Enriched in Polyunsaturated Fatty Acids on Hyperlipoproteinemia in Man.- Atherosclerosis, a Preventable Disease? Autopsy Evidence.- Epidemiological Research in Western Europe.- Platelets in Relation to Atherosclerosis.- Regression of Atherosclerosis.- Problems in Experimental Atherosclerosis.- Some Cellular and Metabolic Aspects of Regression of Atherosclerosis, and the Compensatory Effect of Senile Arterial Dilatation.- Prevention and Regression in Animal Models by Diet and Cholestyramine.- On the Effects of Cholestyramine on Regression of Arterial Lesions in Rhesus Monkeys and of Metformin in Preventing Arterial Lesions in Hypercholesterolemic Rabbits.- Stroke and Heart Attack Induced Experimentally by Thromboxane A2 in Rabbits and Effect of EG 626, a Thromboxane A2 Antagonist.-Prevention and Therapy of Induced Atherosclerosis in Rabbits and Monkeys Regardless of Serum Cholesterol Levels.- Regression of Advanced Atherosclerosis in Swine.- Follow up of Arterial Mural Transport in Model Experiments and the Possibilities of Influencing it.- Immunological Factors in Vascular Diseases.- Pathological Findings Following Immunization with Vascular Tissues.- Microtubules in Arterial Smooth Muscle Cells in Vivo and in Culture An Electron Microscope Study.- Arteriosclerosis of Rats Induced by Fat-Free Diet.- Vascular Smooth Muscle Cells in Culture after Experimental Diabetes.- Alteration of DNA Template Activity in Artery Wall Cells Induced by Risk Factors.- Drugs and Hormones.- Role of Vasoactive Agents and Hypertension in Accelerated Atherogenesis.- Biosynthesis and Degradation of Matrix Macromolecules of the Arterial Wall. Regulation by Drug Action.- Mortality in Longterm Survivors from Myocardial Infarction after D-Penicillamine Therapy.- Effect of Mesenchyme Suppressive Drugs on Sclerogenesis in Animal Models.- A Factor in Diabetic Serum Stimulating Proliferation of Arterial Medial Cell Culture.- Large Vessel Disease in Diabetics - A Specific Diabetic Angiopathy?.- Inhibitory Influence of Somatostatin (Growth-Hormone-Release-Inhibiting-Factor; SRIF) on Mesenchymal Cells of Rats.- Influence of Hormones on Arterial Smooth Muscle Cell Proliferation.- In Vitro Effects of Estrogen on Cyclic Nucleotides in the Arterial Wall.- Effect of Prednisolone and D-Penicillamine on Toxin and LDL Induced Proliferative Activity of ASMC of the Minipig.- Lipid Problems.- Serum Triglycerides and High Density Lipoprotein Cholesterol in Healthy Persons and in Coronary Patients without Increased Serum Cholesterol.- Intervention Results in High Risk Individuals of the CBHeart Project in The Netherlands.- Enzyme - Substrate - Product Interactions in the Metabolism and Accumulation of Lipids in the Arterial Wall.- Physicochemical Factors in the Distribution of Plasma Lipoprotein Subunits between the Plasma Lipoproteins and the Arterial Wall.- Some Aspects on the Mechanism of Plasma Triglyceride Hydrolysis.- Risk and Healing Factors.- Arteriography Changes after Partial Ileal Bypass.- Tobacco Smoke as a Risk Factor in the Etiology of Arteriosclerosis.- Stop Smoking Training in Patients with Coronary Heart Disease.- Rehabilitation after Myocardial Infarction.- Prevention of the Clinical Symptoms of Atherosclerosis by Sport.- Causes of Cardiovascular Mortality and Morbidity in a Longitudinal Epidemiological Study.- Secondary Prevention by Physical Exercise in Patients after Myocardial Infarction (A Controlled Study in Randomized Groups of Exercising and Non-Exercising Patients).- Coagulation and Arteriosclerosis.- Plasmatic Coagulation in the Pathogenesis of Arteriosclerosis.- Surface Charge Properties of Endothelium of the Aorta in Young and Old Animals.- Platelet Aggregation in Atherosclerosis and its Inhibition by Antiplatelet Drugs.- Concluding Remarks.- Animal Models.- Human Arteriosclerosis.
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