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In 1969 the first edition of this book aimed to introduce the concepts of statistics and their medical application to readers with no formal training in this area. While retaining this basic aim, the authors have expanded the coverage in each subsequent edition to keep pace with the increasing use and sophistication of statistics in medical research. This fifth edition has undergone major restructuring, with some sections totally rewritten; it is now more logically organised and substantially more user-friendly (with the addition of 'summary boxes' throughout the text) to incorporate the new statistical techniques and approaches that have made an appearance in the last nine years since the last edition. Also, some chapters or chapter headings are specifically marked to signify material that is generally a little more difficult than the material in which it is embedded - such sections or chapters can be omitted at first reading. Several new chapters have been added - "Associations: Chance, Confounded and Causal?" explaining without any formulae the concepts underlying confounding, confidence intervals and p values, and the interpretation of associations observed in research investigations. The other new chapter considers sample size calculations in some detail and provides, in addition to the relevant formulae, useful tables which should give the researcher an indication of the order of magnitude of the number of subjects he or she might require in different situations.