This book brings together sixteen studies by international scholars on the origins and early development of the Latin and Syriac biblical and philosophical commentary traditions. With its breadth and ground-breaking originality, this volume is an indispensable resource not only for specialists, but also for all students and scholars interested in late-antique intellectual history, especially the practice of teaching and studying philosophy, the philosophical exegesis of the Bible, and the role of commentary in the post-Hellenistic world as far as the classical renaissance in Islam.