Interproximal reduction (IPR) technique involves the reduction, anatomic Recontouring and protection of proximal enamel surface of teeth. It is an important adjunct to extraction of teeth on the border line cases to gain space for relieving crowding. It is also used to correct Bolton index discrepancies and prevent relapse. There are various IPR techniques including mechanical, air-rotor or chemical stripping methods. In this book, we are explaining the techniques and their advantages and disadvantages. Also, the clinical concerns following IPR like increased enamel surface roughness, gingival inflammation, periodontal tissue breakdown, gingival recession or increased sensitivity are explained with available solutions.