Microorganisms play a significant role in the development and progression of pulp and periapical diseases. The primary objective of endodontic therapy is to eradicate root canal infection and create an environment in which any residual microorganisms cannot survive. This can be achieved by employing a combination of aseptic treatment techniques, chemomechanical preparation of the root canal, antimicrobial irrigating solutions and intracanal medicaments. Intracanal medicaments would include any agent with intended pharmacological action introduced in the root canal. While irrigating solutions also demonstrate antibacterial action, intracanal medications more concisely describe medicaments left in the root canal to exert their effects over a longer time period. The popular agents include calcium hydroxide, antibiotics, non-phenolic biocides, phenolic biocides and iodine compounds. Their choice depends upon the pulpal and periapical status of the case being treated.