Endodontic treatment are essentially debridement procedures to disrupt and remove the microbial ecosystem that is associated with disease process. It is important that clinician should understand the close relationship between the presence of microorganisms and endodontic disease processes to develop an effective rationale for treatment.Intracanal medicaments in endodontics have been used for the reduction in the number of microorganisms, rendering canal content static, prevention of post treatment pain and to improve anesthesia. In present day dental practice, intracanal medicaments are being applied in certain conditions for gaining utmost success of root canal treatment. However, all of the currently available antimicrobial materials for root canal irrigation and medication have limitations, and the search continues for the ideal irrigant and intra-appointment medicament.