This is the second edition of the comprehensive and succinct account of basic principles and techniques of diagnostic histopathology, aimed at trainees in this discipline. Following a general introduction, the book gives a description of basic histopathological methods, such as tissue sampling and histological stains. Special techniques, including frozen sections, cytopathology, immunohistology, electron microscopy, and quantitive methods, are described in separate chapters. The methods of interpreting histological images and common causes of diagnostic difficulty are extensively illustrated.…mehr
This is the second edition of the comprehensive and succinct account of basic principles and techniques of diagnostic histopathology, aimed at trainees in this discipline. Following a general introduction, the book gives a description of basic histopathological methods, such as tissue sampling and histological stains. Special techniques, including frozen sections, cytopathology, immunohistology, electron microscopy, and quantitive methods, are described in separate chapters. The methods of interpreting histological images and common causes of diagnostic difficulty are extensively illustrated. This new edition has been thoroughly revised and contains four new chapters, including quality control in histopathology and the autopsy. It is directly relevant to the activities of histopathologists and surgical pathologists, and will also be of value to physicians and surgeons in various specialties who use biopsies in clinical diagnosis.
1 Diagnostic Histopathology.- Origins of Histopathology.- The Objectives of Histopathology.- Medicolegal Aspects.- The Histopathological Diagnosis.- Adverse Effects of Biopsy.- Prospects for Histopathology.- 2 Macroscopy, Microscopy and Sampling.- Sampling Error.- Sampling Biopsies and Surgical Resections.- Specific Types of Biopsy.- Specimen Radiology.- Section Thickness.- Imprints and Smears.- Information and Magnification.- 3 The Use of Stains.- Principles of Staining.- Indications for Special Stains.- Identification of Specific Substances and Cells.- Autoradiography.- 4 Immunohistology.- Techniques for Immunohistology.- Primary Antibodies.- Bridging Reagents.- Tracer Substances.- Fixation.- Use of Enzymes to Unmask Antigens.- Endogenous Peroxidase.- Controls.- Common Applications.- Problems of Interpretation.- Immuno-electron Microscopy.- 5 Interpretation of Histological Appearances.- Artifact of Sections.- Basic Microscopy.- Artifacts in Sections.- Methods of Interpretation.- Clinicopathological Integration.- Morphology of Disease Processes.- 6 Cytology.- Relative Merits of Cytology and Histology.- Cytological Preparations.- Stains for Cytology.- Special Investigations.- Interpretation.- Applications.- Living Cells.- Reporting Cytology.- 7 Borderline Lesions, Pseudomalignancy and Mimicry.- Borderline Lesions.- Mimicry of Histological Features.- Pseudomalignancy and Related Diagnostic Problems.- Conclusions.- 8 Rapid Frozen Section Diagnosis.- Clinical Indications.- Methods.- Interpretation.- Common Applications.- Reliability.- 9 Diagnostic Electron Microscopy.- Principles of Transmission Electron Microscopy.- Diagnostic Value of Electron Microscopy.- Scanning Electron Microscopy.- X-ray Microanalysis.- 10 Quantitative Methods.- Stereological Principles.- Stereological Methods.- Automatic and Semi-automatic Image Analysis.- Microspectrophotometry.- Flow Cytometry.- Practical Applications.- 11 Reporting and Classification of Biopsy Diagnoses.- The Biopsy Report.- Disease Classification.- Data Storage and Retrieval.- Clinical Assimilation.- 12 Quality Assessment and Control.- Sources of Diagnostic Error.- The "Correct" Diagnosis.- Evaluation of Diagnostic Methods.- Evaluation of Performance.- Illustrative Examples.- Self Assessment.- Assessment of Errors of Procedure and Communication.- Conclusions.- 13 The Autopsy.- History of the Autopsy.- The Autopsy and Clinical Audit.- Role in Medical Education.- Hazards in the Autopsy Room.- Consent.- General Techniques.- Special Methods.- Post-mortem Histology.Contents: Diagnostic Histopathology.- Macroscopy, Microscopy and Sampling.- The Use of Stains.- Immunohistology.- Interpretation of Histological Appearances.- Cytology.- Borderline Lesions, Pseudomalignancy and Mimicry.- Rapid Frozen Section Diagnosis.- Diagnostic Electron Microscopy.- Quantitative Methods.- Reporting and Classification of Biopsy Diagnoses.- Quality Assessment and Control.- The Autopsy.- Subject Index.
1 Diagnostic Histopathology.- Origins of Histopathology.- The Objectives of Histopathology.- Medicolegal Aspects.- The Histopathological Diagnosis.- Adverse Effects of Biopsy.- Prospects for Histopathology.- 2 Macroscopy, Microscopy and Sampling.- Sampling Error.- Sampling Biopsies and Surgical Resections.- Specific Types of Biopsy.- Specimen Radiology.- Section Thickness.- Imprints and Smears.- Information and Magnification.- 3 The Use of Stains.- Principles of Staining.- Indications for Special Stains.- Identification of Specific Substances and Cells.- Autoradiography.- 4 Immunohistology.- Techniques for Immunohistology.- Primary Antibodies.- Bridging Reagents.- Tracer Substances.- Fixation.- Use of Enzymes to Unmask Antigens.- Endogenous Peroxidase.- Controls.- Common Applications.- Problems of Interpretation.- Immuno-electron Microscopy.- 5 Interpretation of Histological Appearances.- Artifact of Sections.- Basic Microscopy.- Artifacts in Sections.- Methods of Interpretation.- Clinicopathological Integration.- Morphology of Disease Processes.- 6 Cytology.- Relative Merits of Cytology and Histology.- Cytological Preparations.- Stains for Cytology.- Special Investigations.- Interpretation.- Applications.- Living Cells.- Reporting Cytology.- 7 Borderline Lesions, Pseudomalignancy and Mimicry.- Borderline Lesions.- Mimicry of Histological Features.- Pseudomalignancy and Related Diagnostic Problems.- Conclusions.- 8 Rapid Frozen Section Diagnosis.- Clinical Indications.- Methods.- Interpretation.- Common Applications.- Reliability.- 9 Diagnostic Electron Microscopy.- Principles of Transmission Electron Microscopy.- Diagnostic Value of Electron Microscopy.- Scanning Electron Microscopy.- X-ray Microanalysis.- 10 Quantitative Methods.- Stereological Principles.- Stereological Methods.- Automatic and Semi-automatic Image Analysis.- Microspectrophotometry.- Flow Cytometry.- Practical Applications.- 11 Reporting and Classification of Biopsy Diagnoses.- The Biopsy Report.- Disease Classification.- Data Storage and Retrieval.- Clinical Assimilation.- 12 Quality Assessment and Control.- Sources of Diagnostic Error.- The "Correct" Diagnosis.- Evaluation of Diagnostic Methods.- Evaluation of Performance.- Illustrative Examples.- Self Assessment.- Assessment of Errors of Procedure and Communication.- Conclusions.- 13 The Autopsy.- History of the Autopsy.- The Autopsy and Clinical Audit.- Role in Medical Education.- Hazards in the Autopsy Room.- Consent.- General Techniques.- Special Methods.- Post-mortem Histology.Contents: Diagnostic Histopathology.- Macroscopy, Microscopy and Sampling.- The Use of Stains.- Immunohistology.- Interpretation of Histological Appearances.- Cytology.- Borderline Lesions, Pseudomalignancy and Mimicry.- Rapid Frozen Section Diagnosis.- Diagnostic Electron Microscopy.- Quantitative Methods.- Reporting and Classification of Biopsy Diagnoses.- Quality Assessment and Control.- The Autopsy.- Subject Index.
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