Taking a learning-by-doing approach, this tutorial-style book helps newcomers quickly and easily grasp the essence of adaptive designs as well as the foundations of adaptive design methods. It reduces the mathematics to a minimum and makes the material as practical as possible. The author includes R functions that enable readers to better understand the algorithms and customize the designs to meet their needs. For those with no R experience, an appendix provides a 30-minute R tutorial.
Taking a learning-by-doing approach, this tutorial-style book helps newcomers quickly and easily grasp the essence of adaptive designs as well as the foundations of adaptive design methods. It reduces the mathematics to a minimum and makes the material as practical as possible. The author includes R functions that enable readers to better understand the algorithms and customize the designs to meet their needs. For those with no R experience, an appendix provides a 30-minute R tutorial.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Mark Chang is vice president of biometrics at AMAG Pharmaceuticals and an adjunct professor at Boston University. Dr. Chang is an elected fellow of the American Statistical Association and a co-founder of the International Society for Biopharmaceutical Statistics. He serves on the editorial boards of statistical journals and has published eight books, including Principles of Scientific Methods, Paradoxes in Scientific Inference, Modern Issues and Methods in Biostatistics, Monte Carlo Simulation for the Pharmaceutical Industry, and Adaptive Design Theory and Implementation Using SAS and R, Second Edition.
Inhaltsangabe
Introduction. Classical Design. Two Stage Adaptive Confirmatory Design Method. K Stage Adaptive Confirmatory Design Methods. Sample Size Reestimation Design. Special Two Stage Group Sequential Trials. Pick the Winners Design. The Add Arms Design. Biomarker Adaptive Design. Response Adaptive Randomization. Adaptive Dose Escalation Trial. Deciding Which Adaptive Design to Use. Monitoring Trial and Making Adaptations. Data Analyses of Adaptive Trials. Planning and Execution. Appendices. Bibliography. Index.
Introduction. Classical Design. Two Stage Adaptive Confirmatory Design Method. K Stage Adaptive Confirmatory Design Methods. Sample Size Reestimation Design. Special Two Stage Group Sequential Trials. Pick the Winners Design. The Add Arms Design. Biomarker Adaptive Design. Response Adaptive Randomization. Adaptive Dose Escalation Trial. Deciding Which Adaptive Design to Use. Monitoring Trial and Making Adaptations. Data Analyses of Adaptive Trials. Planning and Execution. Appendices. Bibliography. Index.
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