Introductory Review on Sirtuins in Biology, Aging, and Disease

Herausgeber: Guarente, Leonard; Kazantsev, Aleksey; Mostoslavsky, Raul

• Broschiertes Buch

Produktbeschreibung

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.--

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Produktdetails

• Verlag: Elsevier Science Publishing Co Inc
• Seitenzahl: 220
• Erscheinungstermin: 25. April 2018
• Englisch
• Abmessung: 231mm x 191mm x 15mm
• Gewicht: 472g
• ISBN-13: 9780128134993
• ISBN-10: 0128134992
• Artikelnr.: 49680560

Inhaltsangabe

1. Early Sirtuin Research 1991-2000 2. Regulation of sirtuins by systemic
NAD+ biosynthesis 3. NAD modulation - biology and therapy 4. The enzymatic
activity of sirtuins 5. Molecular mechanisms of Sirtuin activation and
inhibition 6. Pharmacological approaches for modulating sirtuins 7.
Mitochondrial Sirtuins 8. Biological Roles and Activities for Mitochondrial
Sirtuins 9. The multitasking roles of the mammalian deacetylase SIRT6 10.
Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond
11. Sirtiuns and Carcinogenesis 12. Roles for sirtuins in cardiovascular
biology 13. Sirtuins in Brain Biology and Disease