A magical recently discovered hormone named after the Greek Goddess Iris, also known as exercise hormone due to its increase during physical exercise, induces a brown-like phenotype in some white adipocytes. Thus, it improves multiple metabolic parameters by increasing energy expenditure. It plays protective role against various conditions, such as obesity and its associated chronic inflammatory states, cardiovascular diseases, type II diabetes mellitus, fatty liver diseases, cancer as well as osteoporosis and neurodegenerative diseases. We present "IRISN HORMONE"