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Present study discusses irreversibility analysis for peristaltic movement of nanofluid. Viscosity of nanofluid is assumed to vary with local concentration of colloidal particles. Impacts of thermophoresis, magnetic field, Brownian motion, Ohmic heating, viscous dissipation and buoyant forces are considered in flow analysis. Equations representing the flow and heat/mass transfer are prepared by employing Buongiorno's model for nanofluids. Lubrication approach is used to simplify the governing equations. Resulting system of differential equations is numerically solved with the aid of NDSolve in Mathematica. Results for entropy generation, Bejan number, velocity, temperature and concentration are graphically presented. Outcomes show that entropy generation and temperature reduce by increasing the values of viscosity parameter. By increasing buoyancy forces due to temperature difference entropy generation increases whereas concentration profile shows decreasing behavior. Maximum velocity reduces with an increment in Hartman number.