The success of endodontic treatment depends on the eradication of microbes(if present) from the root-canal system and prevention of reinfection. The root canalis shaped with hand and rotary instruments under constant irrigation to remove theinflamed and necrotic tissue, microbes/biofilms, and other debris from the root-canalspace. The main goal of instrumentation is to facilitate effective irrigation, disinfection,and filling. Several studies using advanced techniques such as microcomputedtomography (CT) scanning have demonstrated that proportionally large areas of themain root-canal wall remain untouched by the instruments,1 emphasizing the importanceof chemical means of cleaning and disinfecting all areas of the root canaland there is no single irrigating solution that alone sufficiently covers allof the functions required from an irrigant