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An actinide dependent shadow biosphere of archaea and viroids in the above mentioned disease states is described. Metal actinides in beach sands have been postulated to play a role in abiogenesis. Cholesterol is the primal prebiotic molecule synthesized on actinide surfaces with all other biomolecules arising from it. A self replicating cholesterol lipid organism could be the initial life form. A cholesterol based abiogenesis is a more likely evolutionary option and the actinidic archaea and viroids would have evolved from it. The viruses, prokaryotes and eukaryotes would have evolved from the initial isoprenoid organism derived actinidic archaea. The origin of primates and humans depends on archaeal symbiosis and symbiotic evolution.