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This book contains information on research work done on sample collected only from Bomala area of Gombe State Nigeria and chemically analyzed in Bayero University Kano laboratories while spectroscopic analysis where conducted at both NARICT Ahmadu Bello University Zaria, South Africa and the United Kingdom. The book provides scientific evidence on using Sterculia setigera in the treatment of malaria fever world wide and a possible future synthesis of antimalarial drug from the plant.