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Itraconazole nanoparticles with suitable size ranges are expected to improve the therapeutic efficacy and reduction of toxicity of this broad spectrum antifungal agent. Components of the SLNs were lipid (palmitic acid) and surfactants (Pluronic F127 and Tween 40). The Itraconazole loaded nanoparticles were prepared by microemulsion dispersion method. Particles size analysis and zeta potential measurements were done using Malvern Mastersizer Hydro 2000G. The particles were also subjected to DSC, IR and XRD analyses.The study elaborates on the feasibility and suitability of lipid based colloidal drug delivery system, employing optimize design to develop a clinically useful nanoparticle system with targeting potential. It is expected that this type of itraconazole loaded lipid nanoparticulate system could be clinically effective in better management of systemic and ocular inflammation with greater degree of safety and efficacy. Therefore, no doubt that the book will be of great use for the researchers those who are working on nano drug delivery system for BCS class drugs in India and abroad as well.