Jasper's Basic Mechanisms of the Epilepsies
Herausgeber: Noebels, Jeffrey L; Delgado-Escueta, Antonio V; Vezzani, Annamaria; Rogawski, Michael A; Avoli, Massimo
Jasper's Basic Mechanisms of the Epilepsies
Herausgeber: Noebels, Jeffrey L; Delgado-Escueta, Antonio V; Vezzani, Annamaria; Rogawski, Michael A; Avoli, Massimo
- Gebundenes Buch
- Merkliste
- Auf die Merkliste
- Bewerten Bewerten
- Teilen
- Produkt teilen
- Produkterinnerung
- Produkterinnerung
This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and…mehr
- Phillip L PearlInherited Metabolic Epilepsies190,99 €
- Leonard F. KoziolSubcortical Structures and Cognition204,99 €
- Chrysostomus P. PanayiotopoulosIdiopathic Generalised Epilepsies33,99 €
- Holistic Perspectives on Trauma195,99 €
- Horace B. DayThe Opium Habit36,99 €
- The Societal Burden of Child Abuse168,99 €
- Research for the Radiation Therapist179,99 €
-
-
-
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
- Produktdetails
- Verlag: Hurst & Co.
- 5th edition
- Seitenzahl: 1752
- Erscheinungstermin: 7. Mai 2024
- Englisch
- Abmessung: 274mm x 188mm x 74mm
- Gewicht: 2790g
- ISBN-13: 9780197549469
- ISBN-10: 0197549462
- Artikelnr.: 67981070
- Verlag: Hurst & Co.
- 5th edition
- Seitenzahl: 1752
- Erscheinungstermin: 7. Mai 2024
- Englisch
- Abmessung: 274mm x 188mm x 74mm
- Gewicht: 2790g
- ISBN-13: 9780197549469
- ISBN-10: 0197549462
- Artikelnr.: 67981070
* DEDICATION
* ACKNOWLEDGMENTS
* SECTION 1 - EVOLVING CONCEPTS
* 1. The Paroxysmal Depolarizing Shift (PDS): The First Cellular Marker
of Focal Epileptogenesis
* David Prince and Massimo Avoli
* 2. Hippocampal Sclerosis in Temporal Lobe Epilepsy: New Views and
Challenges
* Carolyn Houser
* 3. Cerebral Cortical Dysplasia or Dysgenesis: Keratan Sulfate
Proteoglycan for Fetal Axonal Guidance and Excitatory/Inhibitory
Synaptic Targets that Influence Epileptogenesis
* Harvey Sarnat and Laura Flores-Sarnat
* 4. mTOR in Acquired and Genetic Models of Epilepsy
* Michael Wong, Angelique Bordey, and Steve C. Danzer
* 5. Epilepsy Genomics: Disease Causing Sequence Variants
* Antonio Delgado-Escueta
* SECTION 2 - SEIZURES, NETWORKS and SYSTEMS
* Editor: Massimo Avoli; Associate Editors: Christophe Bernard and
Marco de Curtis
* Introduction
* Massimo Avoli, Marco de Curtis, Christophe Bernard, and Ivan Soltesz
* 6. GABAa-Receptor Signaling and Ionic Plasticity in the Generation
and Spread of Seizures
* Kai Kaila, Andrew Trevelyan, Joseph Raimondo, Tommi Ala-Kurikka,
Gilles Huberfeld, Massimo Avoli, and Marco de Curtis
* 7. Connexins, Pannexins and Epilepsy
* Liang Zhang, Georg R. Zoidl, and Peter L. Carlen
* 8. Mechanisms Leading to Initiation, Development and Termination of
Focal Seizures
* Marco de Curtis, Piotr Suffczynski, Maxime Lévesque, Laura
Librizzi,Laura Uva, Paolo Scalmani, Vadym Gnatkovsky, and Massimo
Avoli
* 9. Transition to Seizure from Cellular, Network, and Dynamical
Perspectives
* Wei-Chih Chang, Jan Kudlacek, Premysl Jiruska, and John G.R. Jefferys
* 10. Role of the Subiculum in Focal Epilepsy
* Alesya Evstratova, Belén Diaz-Fernandez, Maxime Lévesque, Massimo
Avoli, and Gand illes Huberfeld
* 11. Optogenetic Modulation of Focal Seizures
* Maxime Lévesque, Massimo Avoli, and Merab Kokaia
* 12. Balancing Seizure Control with Cognitive Side-Effects
* Sheela Tropani, Gene G Gurkoff, Kiarash Shahlaie, Fady Girgis,
Ignacio Saez, Jeffrey Kennedy, and Karen A Moxon
* 13. High Frequency Oscillations
* Liset Menendes de la Prida and Jean Gotman
* 14. Seizures and Sleep
* Birgit Frauscher and Igor Timofeev
* 15. Cycles in epilepsy
* Maxime Baud, Vikram Rao, Christophe Bernard, and Philippa Karoly
* 16. Human Single Unit Recordings in Epilepsy
* Edward Merricks and Catherine Schevon
* 17. Role of Ion Concentration Dynamics in Epileptic Seizures
* Oscar C González, Igor Timofeev, and Maxim Bazhenov
* 18. A Classification of Seizures Based on Dynamics
* Hiba Sheheitli, Huifang Wang, Jean-Didier Lemarechal, Christophe
Bernard, and Viktor K. Jirsa
* 19. Seizures, Networks and Systems - Computational EEG Analysis of
Human Epileptogenic Networks
* Vadim Gnatkovsky and Kaspar Schindler
* 20. Excitation-Inhibition Balance in Absence Seizure Ictogenesis
* Magor L. Lõrincz, Vincenzo Crunelli, and Francois David
* 21. Cortical and Thalamic PV+ Interneuron Dysfunction in the
Pathogenesis of Absence Epilepsy
* Jochen Meyer and Atul Maheshwari
* 22. Convergence of Thalamic Mechanisms in Genetic Epilepsies
* Frances Cho and Jeanne Paz
* Section 3 - EPILEPTOGENESIS: MOLECULAR MECHANISMS and TREATMENTS
* Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and
David Henshall
* Introduction
* Annamaria Vezzani and Helen Scharfman
* 23. The Diverse Roles of Mossy Cells in the Normal Brain,
Epileptogenesis, and Chronic Epilepsy
* Helen Scharfman
* 24. Temporal Lobe Epileptogenesis; A Focus on Etiology, Neuron Loss,
The Latent Period, and Dentate Granule Cell Disinhibition
* Robert Sloviter
* 25. Adult Neurogenesis in Epileptogenesis and Comorbidities
* Kyung-Ok Cho and Jenny Hsieh
* 26. A Crucial Role for Astrocytes in Epileptogenesis: Gap Junctions
and Glutamate Receptors
* Peter Bedner, Allison R. Peterson, DevinK.Binder, Christian
Steinhäuser
* 27. Adenosine Kinase: Cytoplasmic and Nuclear Isoforms
* Madhuvika Murugan and Detlev Boison
* 28. Inflammatory Astrocytic TGFß- Signaling Induced by Blood-Brain
Barrier Dysfunction Drives Epileptogenesis
* Lynn T. Yang, Giovanni Anthony, and Daniela Kaufer
* 29. Pericytes and Microglia: Neurovascular and Immune Regulatory
Cells in Seizure Disorders
* Nicola Marchi and Amy Brewster
* 30. Neuroinflammation in Epilepsy: Cellular and Molecular Mechanisms
* Ray Dingledine, Nicholas Varvel, Teresa Ravizza, and Annamaria
Vezzani
* 31. Role of Reactive Oxygen Species in Epilepsy
* Ashwini Sri Hari, Matthew C. Walker, and Manisha Patel
* 32. BDNF/TrkB Signaling and Epileptogenesis
* Stephen Harward, Yang Huang, and James McNamara
* 33. Clinical Features and Molecular Mechanisms Underlying
Autoantibody-Mediated Seizures
* Alexander Mathy and Sarosh Irani
* 34. Transcriptomic Alterations in Epileptogenesis: Transcription
Factors in the Spotlight
* Gary Brennan and Karen van Loo
* 35. Epigenetics
* Katja Kobow and Nadia Khan
* SECTION 4 - BIOMARKERS OF EPILEPTOGENESIS
* Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and
David Henshall
* Introduction
* Annamaria Vezzani and David Henshall
* 36. EEG Biomarkers of Epileptogenesis
* Lyna Kamintsky, Dan Z Milikovsky, and Alon Friedman
* 37. Blood Biomarkers: Noncoding RNAs and Proteins
* David Henshall and Michele Simonato
* 38. Behavioural Biomarkers of Epileptogenesis and Epilepsy Severity
* Idrish Ali, Pablo Casillas-Espinosa, Nigel Jones, and Terence O'Brien
* 39. Genetic and Imaging Biomarkers of Epileptogenesis
* Matthias Koepp, Simona Balestrini, Stefanie Dedurwaerdere, and
William Theodore
* 40. Machine-Learning Approach to Discover Novel Biomarkers for
Post-Traumatic Epilepsy
* Robert Ciszek, Eppu Manninen, Olli Gröhn, Jussi Tohka, and Asla
Pitkänen
* SECTION 5 - GENES AND NETWORK DEVELOPMENT
* Editors: Antonio Delgado Escueta and Jeffrey Noebels; Associate
Editor: Elsa Rossignol
* Introduction
* Jeffrey Noebels
* 41. Human Epilepsy Gene Discovery: The Next Decade
* Emily Bonkowski and Heather Mefford
* 42. Functional Exploration of Epilepsy Genes in Patint-Derived Cells
* Maria 'Carmen' Varela, Ranmal Samarasinghe, and Jack Parent
* 43. Brain mosaicism in Epileptogenic Cortical Malformations
* Théo Ribierre and Stéphanie Baulac
* 44. Sodium Channelopathies in Human and Animal Models of Epilepsy and
Neurodevelopmental Disorders
* Kazuhiro Yamakawa, Miriam Meisler, and Lori Isom
* 45. Potassium Channels in Genetic Epilepsy: a Functional Perspective
* Matthew Weston and Anastasios Tzingounis
* 46. High Voltage Activated Calcium Channels in Epilepsy: Lessons from
Humans and Rodents
* Elsa Rossignol
* 47. Transcription Factors Regulating Interneuron Development
* Emily Ling-Lin Pai, Daniel Vogt, Jia Sheng Hu, and John Rubenstein
* 48. GABAA Receptors, Seizures and Epilepsy
* Richard Olsen, Martin Wallner, and Michael A. Rogawski
* 49. Gene genome interactions - Understanding complex molecular traits
in epilepsy
* Katja Kobow and John Mahoney
* SECTION - 6 PROGRESSIVE MYOCLONUS EPILEPSIES
* Editor: Antonio Delgado-Escueta; Associate Editor: Berge Minassian
* Introduction
* A.V. Delgado-Escueta, Berge Minassian, Jose M Seratossa
* 50. The Neuronal Ceroid Lipofuscinoses
* Sara Mole
* 51. Progressive Myoclonus Epilepsy: Unverricht-Lundborg Disease
* Saara Tegelberg, Tarja Joensuu, and Anna-Elina Lehesjoki
* 52. Strategies on Gene Therapy in Progressive Myoclonus Epilepsies
* Saima Kayani, Emrah Gumusgoz, Berge Minassian, and Alison Dolce
* 53. Therapeutic Window for the Treatment of Lafora Disease
* Olga Varea, Joan Guinovart, and Jordi Duran
* 54. Progressive Myoclonus Epilepsy of Lafora- Treatment with
Metformin
* Jose M. Seratossa, Daniel F. Burgos, Luis Zafra-Puerta, Nerea
Iglesias-Cabeza, Pascual Sanz, and Marina P. Sánchez
* 55. Treating Lafora Disease with an Antibody-Enzyme Fusion
* Matthew Gentry, Kia H. Markussen, Ramon Sun, and Craig W. Vander Kooi
* 56. Antisense Oligonucleotide Therapy for Progressive Myoclonus
Epilepsies
* Silvia Nitschke and Berge Minassian
* SECTION 7 - COMORBIDITIES OF EPILEPTIC NETWORKS
* Editor: Jeffrey Noebels; Associate Editor: Peyman Golshani
* Introduction
* Jeffrey Noebels
* 57. Dissecting Epileptic and Cognitive Network Dysfunction in
Epilepsy
* Pierre-Pascal Lenck-Santini and Greg Holmes
* 58. Attention Deficit Disorders and Epilepsy
* Atul Maheshwari
* 59. What Rodent Models Teach Us About the Association of Autism and
Epilepsy
* Peyman Golshani
* 60. Artificial Intelligence-Guided Behavioral Phenotyping in Epilepsy
* Tilo Gschwind and Ivan Soltesz
* 61. Mechanisms of Depression in the Epileptic Brain
* Nigel Jones and Jamie Maguire
* 62. Heterogeneous Mechanisms of Spreading Depolarization and Seizures
* Isamu Aiba
* 63. Genetic and Cellular Mechanisms Underlying SUDEP Risk
* Jeffrey Noebels
* SECTION 8- EPILEPSY THERAPEUTICS
* Editor: Michael Rogawski; Associate Editors: Wolfgang Löscher and
Steve White
* Introduction
* Michael Rogawski
* 64. New Models for Assessment of Antiseizure Activity
* Cameron Metcalf, Peter West, Sharon Edwards, and Karen Wilcox
* 65. Disease Biology Factors Accounting for Epilepsy Severity: An
Updated Conceptual Framework for New Drug Discovery
* Stefanie Dedeurwaerdere, Vincenzo Marra, and Michael R Johnson
* 66. Animal Models of Pharmacoresistant Epilepsy
* Michelle Guignet and H. Steve White
* 67. Drug Combinations for Antiepileptogenesis
* Wolfgang Löscher
* 68. Prophylaxis of Epileptogenesis in Injury and Genetic Epilepsy
Models
* David Prince and Feng Gu
* 69. Management of Febrile Status Epilepticus: Past, Present and
Future
* Megan M. Garcia-Curran and Tallie Z. Baram
* 70. Excitatory Transmission in Status Epilepticus
* Suchitra Joshi and Jaideep Kapur
* 71. Ionic Mechanisms of Ictogenic Disinhibition: All GABA Signaling
is Local
* Kevin Staley
* 72. Epileptogenic Channelopathies Guide Design of NBI-921352, a
Highly Isoform-Selective Inhibitor of NaV1.6
* J.P. Johnson, Jr, Alison J Cutts, James R. Empfield, and Charles J.
Cohen
* 73. Purinergic Signaling in Epilepsy
* Tobias Engel and Nicholas Dale
* 74. Anti-Inflammatory Strategies for Disease Modification: Focus on
Therapies Close to Clinical Translation
* Annamaria Vezzani, Silvia Balosso, Nicholas H. Varvel, and Ray
Dingledine
* 75. Targeted Augmentation of Nuclear Gene Output (TANGO)
* Lori Isom and Kelly G. Knupp
* 76. Gene Therapy for Epilepsy
* Kimberly Goodspeed, Dallas Armstrong, Andrea Boitnott, Alison Dolce,
Qinglan Ling, and Steve Gray
* 77. Gene Therapy for Refractory Epilepsy
* Dimitri Kullmann
* 78. Cell Therapy for Treatment of Epilepsy
* Sonja Bröer and Daniel Vogt
* 79. Mechanisms of Ketogenic Diet Action
* Robin Williams, Detlev Boison, Susan Masino, and Jong Rho
* DEDICATION
* ACKNOWLEDGMENTS
* SECTION 1 - EVOLVING CONCEPTS
* 1. The Paroxysmal Depolarizing Shift (PDS): The First Cellular Marker
of Focal Epileptogenesis
* David Prince and Massimo Avoli
* 2. Hippocampal Sclerosis in Temporal Lobe Epilepsy: New Views and
Challenges
* Carolyn Houser
* 3. Cerebral Cortical Dysplasia or Dysgenesis: Keratan Sulfate
Proteoglycan for Fetal Axonal Guidance and Excitatory/Inhibitory
Synaptic Targets that Influence Epileptogenesis
* Harvey Sarnat and Laura Flores-Sarnat
* 4. mTOR in Acquired and Genetic Models of Epilepsy
* Michael Wong, Angelique Bordey, and Steve C. Danzer
* 5. Epilepsy Genomics: Disease Causing Sequence Variants
* Antonio Delgado-Escueta
* SECTION 2 - SEIZURES, NETWORKS and SYSTEMS
* Editor: Massimo Avoli; Associate Editors: Christophe Bernard and
Marco de Curtis
* Introduction
* Massimo Avoli, Marco de Curtis, Christophe Bernard, and Ivan Soltesz
* 6. GABAa-Receptor Signaling and Ionic Plasticity in the Generation
and Spread of Seizures
* Kai Kaila, Andrew Trevelyan, Joseph Raimondo, Tommi Ala-Kurikka,
Gilles Huberfeld, Massimo Avoli, and Marco de Curtis
* 7. Connexins, Pannexins and Epilepsy
* Liang Zhang, Georg R. Zoidl, and Peter L. Carlen
* 8. Mechanisms Leading to Initiation, Development and Termination of
Focal Seizures
* Marco de Curtis, Piotr Suffczynski, Maxime Lévesque, Laura
Librizzi,Laura Uva, Paolo Scalmani, Vadym Gnatkovsky, and Massimo
Avoli
* 9. Transition to Seizure from Cellular, Network, and Dynamical
Perspectives
* Wei-Chih Chang, Jan Kudlacek, Premysl Jiruska, and John G.R. Jefferys
* 10. Role of the Subiculum in Focal Epilepsy
* Alesya Evstratova, Belén Diaz-Fernandez, Maxime Lévesque, Massimo
Avoli, and Gand illes Huberfeld
* 11. Optogenetic Modulation of Focal Seizures
* Maxime Lévesque, Massimo Avoli, and Merab Kokaia
* 12. Balancing Seizure Control with Cognitive Side-Effects
* Sheela Tropani, Gene G Gurkoff, Kiarash Shahlaie, Fady Girgis,
Ignacio Saez, Jeffrey Kennedy, and Karen A Moxon
* 13. High Frequency Oscillations
* Liset Menendes de la Prida and Jean Gotman
* 14. Seizures and Sleep
* Birgit Frauscher and Igor Timofeev
* 15. Cycles in epilepsy
* Maxime Baud, Vikram Rao, Christophe Bernard, and Philippa Karoly
* 16. Human Single Unit Recordings in Epilepsy
* Edward Merricks and Catherine Schevon
* 17. Role of Ion Concentration Dynamics in Epileptic Seizures
* Oscar C González, Igor Timofeev, and Maxim Bazhenov
* 18. A Classification of Seizures Based on Dynamics
* Hiba Sheheitli, Huifang Wang, Jean-Didier Lemarechal, Christophe
Bernard, and Viktor K. Jirsa
* 19. Seizures, Networks and Systems - Computational EEG Analysis of
Human Epileptogenic Networks
* Vadim Gnatkovsky and Kaspar Schindler
* 20. Excitation-Inhibition Balance in Absence Seizure Ictogenesis
* Magor L. Lõrincz, Vincenzo Crunelli, and Francois David
* 21. Cortical and Thalamic PV+ Interneuron Dysfunction in the
Pathogenesis of Absence Epilepsy
* Jochen Meyer and Atul Maheshwari
* 22. Convergence of Thalamic Mechanisms in Genetic Epilepsies
* Frances Cho and Jeanne Paz
* Section 3 - EPILEPTOGENESIS: MOLECULAR MECHANISMS and TREATMENTS
* Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and
David Henshall
* Introduction
* Annamaria Vezzani and Helen Scharfman
* 23. The Diverse Roles of Mossy Cells in the Normal Brain,
Epileptogenesis, and Chronic Epilepsy
* Helen Scharfman
* 24. Temporal Lobe Epileptogenesis; A Focus on Etiology, Neuron Loss,
The Latent Period, and Dentate Granule Cell Disinhibition
* Robert Sloviter
* 25. Adult Neurogenesis in Epileptogenesis and Comorbidities
* Kyung-Ok Cho and Jenny Hsieh
* 26. A Crucial Role for Astrocytes in Epileptogenesis: Gap Junctions
and Glutamate Receptors
* Peter Bedner, Allison R. Peterson, DevinK.Binder, Christian
Steinhäuser
* 27. Adenosine Kinase: Cytoplasmic and Nuclear Isoforms
* Madhuvika Murugan and Detlev Boison
* 28. Inflammatory Astrocytic TGFß- Signaling Induced by Blood-Brain
Barrier Dysfunction Drives Epileptogenesis
* Lynn T. Yang, Giovanni Anthony, and Daniela Kaufer
* 29. Pericytes and Microglia: Neurovascular and Immune Regulatory
Cells in Seizure Disorders
* Nicola Marchi and Amy Brewster
* 30. Neuroinflammation in Epilepsy: Cellular and Molecular Mechanisms
* Ray Dingledine, Nicholas Varvel, Teresa Ravizza, and Annamaria
Vezzani
* 31. Role of Reactive Oxygen Species in Epilepsy
* Ashwini Sri Hari, Matthew C. Walker, and Manisha Patel
* 32. BDNF/TrkB Signaling and Epileptogenesis
* Stephen Harward, Yang Huang, and James McNamara
* 33. Clinical Features and Molecular Mechanisms Underlying
Autoantibody-Mediated Seizures
* Alexander Mathy and Sarosh Irani
* 34. Transcriptomic Alterations in Epileptogenesis: Transcription
Factors in the Spotlight
* Gary Brennan and Karen van Loo
* 35. Epigenetics
* Katja Kobow and Nadia Khan
* SECTION 4 - BIOMARKERS OF EPILEPTOGENESIS
* Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and
David Henshall
* Introduction
* Annamaria Vezzani and David Henshall
* 36. EEG Biomarkers of Epileptogenesis
* Lyna Kamintsky, Dan Z Milikovsky, and Alon Friedman
* 37. Blood Biomarkers: Noncoding RNAs and Proteins
* David Henshall and Michele Simonato
* 38. Behavioural Biomarkers of Epileptogenesis and Epilepsy Severity
* Idrish Ali, Pablo Casillas-Espinosa, Nigel Jones, and Terence O'Brien
* 39. Genetic and Imaging Biomarkers of Epileptogenesis
* Matthias Koepp, Simona Balestrini, Stefanie Dedurwaerdere, and
William Theodore
* 40. Machine-Learning Approach to Discover Novel Biomarkers for
Post-Traumatic Epilepsy
* Robert Ciszek, Eppu Manninen, Olli Gröhn, Jussi Tohka, and Asla
Pitkänen
* SECTION 5 - GENES AND NETWORK DEVELOPMENT
* Editors: Antonio Delgado Escueta and Jeffrey Noebels; Associate
Editor: Elsa Rossignol
* Introduction
* Jeffrey Noebels
* 41. Human Epilepsy Gene Discovery: The Next Decade
* Emily Bonkowski and Heather Mefford
* 42. Functional Exploration of Epilepsy Genes in Patint-Derived Cells
* Maria 'Carmen' Varela, Ranmal Samarasinghe, and Jack Parent
* 43. Brain mosaicism in Epileptogenic Cortical Malformations
* Théo Ribierre and Stéphanie Baulac
* 44. Sodium Channelopathies in Human and Animal Models of Epilepsy and
Neurodevelopmental Disorders
* Kazuhiro Yamakawa, Miriam Meisler, and Lori Isom
* 45. Potassium Channels in Genetic Epilepsy: a Functional Perspective
* Matthew Weston and Anastasios Tzingounis
* 46. High Voltage Activated Calcium Channels in Epilepsy: Lessons from
Humans and Rodents
* Elsa Rossignol
* 47. Transcription Factors Regulating Interneuron Development
* Emily Ling-Lin Pai, Daniel Vogt, Jia Sheng Hu, and John Rubenstein
* 48. GABAA Receptors, Seizures and Epilepsy
* Richard Olsen, Martin Wallner, and Michael A. Rogawski
* 49. Gene genome interactions - Understanding complex molecular traits
in epilepsy
* Katja Kobow and John Mahoney
* SECTION - 6 PROGRESSIVE MYOCLONUS EPILEPSIES
* Editor: Antonio Delgado-Escueta; Associate Editor: Berge Minassian
* Introduction
* A.V. Delgado-Escueta, Berge Minassian, Jose M Seratossa
* 50. The Neuronal Ceroid Lipofuscinoses
* Sara Mole
* 51. Progressive Myoclonus Epilepsy: Unverricht-Lundborg Disease
* Saara Tegelberg, Tarja Joensuu, and Anna-Elina Lehesjoki
* 52. Strategies on Gene Therapy in Progressive Myoclonus Epilepsies
* Saima Kayani, Emrah Gumusgoz, Berge Minassian, and Alison Dolce
* 53. Therapeutic Window for the Treatment of Lafora Disease
* Olga Varea, Joan Guinovart, and Jordi Duran
* 54. Progressive Myoclonus Epilepsy of Lafora- Treatment with
Metformin
* Jose M. Seratossa, Daniel F. Burgos, Luis Zafra-Puerta, Nerea
Iglesias-Cabeza, Pascual Sanz, and Marina P. Sánchez
* 55. Treating Lafora Disease with an Antibody-Enzyme Fusion
* Matthew Gentry, Kia H. Markussen, Ramon Sun, and Craig W. Vander Kooi
* 56. Antisense Oligonucleotide Therapy for Progressive Myoclonus
Epilepsies
* Silvia Nitschke and Berge Minassian
* SECTION 7 - COMORBIDITIES OF EPILEPTIC NETWORKS
* Editor: Jeffrey Noebels; Associate Editor: Peyman Golshani
* Introduction
* Jeffrey Noebels
* 57. Dissecting Epileptic and Cognitive Network Dysfunction in
Epilepsy
* Pierre-Pascal Lenck-Santini and Greg Holmes
* 58. Attention Deficit Disorders and Epilepsy
* Atul Maheshwari
* 59. What Rodent Models Teach Us About the Association of Autism and
Epilepsy
* Peyman Golshani
* 60. Artificial Intelligence-Guided Behavioral Phenotyping in Epilepsy
* Tilo Gschwind and Ivan Soltesz
* 61. Mechanisms of Depression in the Epileptic Brain
* Nigel Jones and Jamie Maguire
* 62. Heterogeneous Mechanisms of Spreading Depolarization and Seizures
* Isamu Aiba
* 63. Genetic and Cellular Mechanisms Underlying SUDEP Risk
* Jeffrey Noebels
* SECTION 8- EPILEPSY THERAPEUTICS
* Editor: Michael Rogawski; Associate Editors: Wolfgang Löscher and
Steve White
* Introduction
* Michael Rogawski
* 64. New Models for Assessment of Antiseizure Activity
* Cameron Metcalf, Peter West, Sharon Edwards, and Karen Wilcox
* 65. Disease Biology Factors Accounting for Epilepsy Severity: An
Updated Conceptual Framework for New Drug Discovery
* Stefanie Dedeurwaerdere, Vincenzo Marra, and Michael R Johnson
* 66. Animal Models of Pharmacoresistant Epilepsy
* Michelle Guignet and H. Steve White
* 67. Drug Combinations for Antiepileptogenesis
* Wolfgang Löscher
* 68. Prophylaxis of Epileptogenesis in Injury and Genetic Epilepsy
Models
* David Prince and Feng Gu
* 69. Management of Febrile Status Epilepticus: Past, Present and
Future
* Megan M. Garcia-Curran and Tallie Z. Baram
* 70. Excitatory Transmission in Status Epilepticus
* Suchitra Joshi and Jaideep Kapur
* 71. Ionic Mechanisms of Ictogenic Disinhibition: All GABA Signaling
is Local
* Kevin Staley
* 72. Epileptogenic Channelopathies Guide Design of NBI-921352, a
Highly Isoform-Selective Inhibitor of NaV1.6
* J.P. Johnson, Jr, Alison J Cutts, James R. Empfield, and Charles J.
Cohen
* 73. Purinergic Signaling in Epilepsy
* Tobias Engel and Nicholas Dale
* 74. Anti-Inflammatory Strategies for Disease Modification: Focus on
Therapies Close to Clinical Translation
* Annamaria Vezzani, Silvia Balosso, Nicholas H. Varvel, and Ray
Dingledine
* 75. Targeted Augmentation of Nuclear Gene Output (TANGO)
* Lori Isom and Kelly G. Knupp
* 76. Gene Therapy for Epilepsy
* Kimberly Goodspeed, Dallas Armstrong, Andrea Boitnott, Alison Dolce,
Qinglan Ling, and Steve Gray
* 77. Gene Therapy for Refractory Epilepsy
* Dimitri Kullmann
* 78. Cell Therapy for Treatment of Epilepsy
* Sonja Bröer and Daniel Vogt
* 79. Mechanisms of Ketogenic Diet Action
* Robin Williams, Detlev Boison, Susan Masino, and Jong Rho