Rapid globalization has contributed to a growing number of expatriates working in foreign countries. The Global Delivery Model followed by the Indian software firms creates a number of international opportunities for Indian software professionals. This study focuses on analyzing the factors influencing expatriate job satisfaction of Indian IT employees working in USA (Florida, Texas, New York). The study discussed how Cultural adjustment influence the work environment and social-cultural adaptation. The survey was conducted among 350 Indian expatriates currently on assignment in Florida, Texas, and New York. The result concludes that there is a positive relationship between work environment, Social-cultural adaptation and Job satisfaction and the study recommends that expatriates have to be trained on host culture and environment to adjustment with the host country and which help to improve expatriate job satisfaction and complete the assignment successfully.