The study was aimed to appraise the knowledge, attitude and perception of physicians and pharmacist towards generic medicines in Kollam district of Kerala. A set of two different questionnaires was framed and validated by a team of physicians and pharmacist, which was given to the population that met the inclusion criteria. The questionaries were also designed in such way to collect the socio-demographic details of the participants. This study was conducted over a period of six months covering most of major hospitals of the study site. A total of 124 physicians and pharmacist was enrolled in this study respectively. The study disclosed the concerns of physicians and pharmacist regarding generic substitution: 67% percent of the enrolled physicians raised the need for bioequivalence study for generics, to ensure its quality was the main concern for physicians, and 47% of them perceived that generic drugs are effective as innovator drugs, while 83% of them stressing the importance to conduct awareness program about the use of generics, while the lack of knowledge among the public regarding the generics was a common concern for physicians and pharmacists, around 76% of the pharmacist.