Andere Kunden interessierten sich auch für
![A Description of Some of the Most Important Ophthalmic Methods Employed for the Recognition of Peripheral and Central Nerve Disease]( "A Description of Some of the Most Important Ophthalmic Methods Employed for the Recognition of Peripheral and Central Nerve Disease")
A Description of Some of the Most Important Ophthalmic Methods Employed for the Recognition of Peripheral and Central Nerve Disease12,90 €![Master of the Universe - Quantal Computing Cloud & Dark Forest Aliens]( "Master of the Universe - Quantal Computing Cloud & Dark Forest Aliens")
Master of the Universe - Quantal Computing Cloud & Dark Forest Aliens54,90 €![Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems]( "Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems")
Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems42,99 €![Principles of Ecology]( "Principles of Ecology")
Principles of Ecology83,99 €![Master of the Universe - Quantal Computing Cloud & Dark Forest Aliens]( "Master of the Universe - Quantal Computing Cloud & Dark Forest Aliens")
Master of the Universe - Quantal Computing Cloud & Dark Forest Aliens39,99 €![Neurohumoral and Metabolic Aspects of Injury]( "Neurohumoral and Metabolic Aspects of Injury")
Neurohumoral and Metabolic Aspects of Injury83,99 €![On Some Forms of Paralysis From Peripheral Neuritis of Gouty, Alcoholic, Diphtheritic, and Other Origin]( "On Some Forms of Paralysis From Peripheral Neuritis of Gouty, Alcoholic, Diphtheritic, and Other Origin")
On Some Forms of Paralysis From Peripheral Neuritis of Gouty, Alcoholic, Diphtheritic, and Other Origin17,90 €
Lymphocytes play a prominent role in the combat of infectious diseases. For a sufficient but limited immune response it is essential that migration and activation of lymphocytes are strictly controlled. The transcription factor KLF2 modulates T lymphocyte egress from lymphoid organs by regulating S1P1. This is not the case for B cells. Instead, KLF2 regulates homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of beta7 integrin. In mice with a B cell-specific deletion of KLF2, S1P1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring less B cells, fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were found. Upon thymus-dependent immunization, IgG titers were diminished and antigen-specific plasma cells were absent in the bone marrow. Furthermore this study provides first evidence that KLF2 is posttranslationally phosphorylated directly or indirectly by the PI3K signaling pathway.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.