Knit Two returns to the Manhattan knitting store, Walker and Daughter, five years after the death of the store's owner, Georgia Walker. Georgia's daughter Dakota is now an eighteen-year-old freshman at NYU, running the knitting store part-time with the help of the members of the Friday Night Knitting Club. Drawn together by their love for Dakota and the sense of family the club provides, each knitter is struggling with new challenges: for Catherine, finding love after divorce; for Darwin, newborn twins; for Lucie, being both a single mom and caregiver for her elderly mother, and for seventy-something Anita, marriage to her sweetheart Marty over the objections of her grown children.