Drug/substance abuse among adolescents is very harmful not limited to their health but to their life careers as well as the social-economic prosperity of any nation because they are the most today's producers and catalysts of economic development. The current trend of drug/substance abuse among adolescents has been given high concern across the world. This Manuscript will contribute genuine intellectual as well as factual oriented actions to preventive and rehabilitative interventions at individual, family, educational, National and international level.