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the study aimed to evaluate knowledge, attitudes and practices (KAP) towards Swine Flu among health care providers at Primary Health Centers in the Gaza Strip. A quantitative, descriptive cross sectional design was used. The study sample included 300 eligible subjects who were selected through a stratified random selection. Self-administered, self-constructed questionnaire was used with a response rate of 93.3%. The questionnaire was validated by experts and reliability analysis was performed using Cronbach Alpha test (0.72). The SPSS program version 14.0 was used to analyze the data. Descriptive analysis followed by t-test and one way ANOVA were performed The health care providers' knowledge about H1N1 was high (92.2%), their attitudes scores were 65.8% and their practices scores were the lowest (60.9%). Also the results reveal that most health care providers (50.5%) have indicated that television, radio and internet were their major sources of information about Swine Flu. Only 31.4% of the providers took the Swine Flu vaccination. Around 30% of the respondents reported that the vaccine for Swine Flu causes many problems.