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This book describes the application of Knowledge Management in the not-for-profit sector, focussing particularly on the Global Fund to fight AIDS, Tuberculosis and Malaria. It is based on the research undertaken by me as part of my MBA at Judge Business School, University of Cambridge. It includes a study on the existing Knowledge Management literature, Knowledge Management processes being practiced in not-for-profit organisations (including WHO, NHS, ILO etc), an analysis of the knowledge available at the Global Fund through a Knowledge Management audit, and makes recommendations on practices that the Global Fund can follow in order to manage their internal knowledge more efficiently. This book is expected to be useful for those from the Not-for-Profit sector to formulate and implement Knowledge Management initiatives.