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Kojic acid represents an attractive multifunctional skeleton for development of biological active compounds. Inventors have prepared great varieties of kojic acid derivatives with selective properties. Thus kojic acid derivatives are promising and advantageous to make human or veterinary medicines and also to prepare more biological active compounds with preferable properties.Kojic acid has many industrial applications and its demand is increasing as it is being applied to many areas regarding to healthcare, agriculture, food processing, cosmetic industries etc. This book describes various fermentation approaches along with applications of kojic acid that can be applied for kojic acid efficient production.