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El ganglio linfático centinela se denomina el foco inicial de la metástasis tumoral a través de los efluvios linfáticos de un tumor primario. La biopsia del ganglio linfático centinela se considera un estándar de oro en la estadificación de los ganglios linfáticos metastásicos en el carcinoma de mama y el melanoma. La biopsia del ganglio linfático centinela ha desplazado eficazmente la intervención invasiva de la disección completa de los ganglios linfáticos axilares (DGLA) en el tratamiento del carcinoma de mama infiltrante. Se puede aplicar de forma convincente una técnica de doble rastreo, una demarcación percutánea del ganglio biopsiado o la utilización de colorante azul. Las recomendaciones y directrices para evaluar adecuadamente el ganglio centinela están bien delineadas.