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Oral leukoplakia (OL) is treated through various medical and surgical approaches aimed at reversing or eliminating changes in the oral mucosa and preventing malignant transformation. Medical interventions involve photodynamic therapy and pharmacological treatments like vitamin A, retinoids, beta carotene, NSAIDs, herbal extracts, bleomycin, and Bowman-Birk inhibitors. Additional treatments include cryotherapy, laser therapy, and cold-knife surgery, each targeting the lesion through different methods. Research on the effectiveness of laser treatment for OL shows varied results, particularly concerning recurrence and malignant transformation. This book aims to better understand the association between treatment outcomes and malignant transformation of OL dealt with lasers and investigate the association between its malignant transformation and related risk factors.