When the moment for Gene to take Nancy to her desired death in Coffeeville arrives, she is unexpectedly admitted to the secure unit of a nursing home and he has to call upon his two remaining friends to help break her out: one his godson, a disgraced weatherman in the throes of a midlife crisis, and the other an ex-army marksman officially dead for 40 years. On a tour bus once stolen from Paul McCartney, and joined by a young orphan boy searching for lost family, the band of misfits career towards Mississippi through a landscape of euthanasia, religion and war.