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This issue of Interventional Cardiology Clinics, edited by Dr. Apostolos Tzikas, will cover several important elements of Left Atrial Appendage Closure. Articles in this issue include, but are not limited to: Ischemic stroke in atrial fibrillation; History of LAAO; Anatomy of the left atrial appendage, including implications for endocardial and epicardial device closure; Indications, patient selection and referral pathways for LAAO; CT for LAAO; The Watchman device; The Amplatzer Amulet device; and The current device landscape and future perspectives.