This study was initiated to investigate the potential of lettuce (Lactuca sativa L. var. buttercrunch) seeds as a bioindicator (BI), or a biological tool for detecting the presence of some toxic materials used in tanning industry and determining their concentrations using the germination percentage as a parameter (indicator). The BIs might help in reducing the cost of analysis and is intended to substitute for the highly sophisticated analytical equipments, which are unaffordable by the developing countries.