Leucine-Rich Repeat Kinase 2 (LRRK2)

Herausgegeben:Rideout, Hardy J.

• Gebundenes Buch

Produktbeschreibung

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Produktdetails

• Advances in Neurobiology 14
• Verlag: Springer / Springer International Publishing / Springer, Berlin
• Artikelnr. des Verlages: 978-3-319-49967-3
• 1st ed. 2017
• Seitenzahl: 292
• Erscheinungstermin: 4. April 2017
• Englisch
• Abmessung: 241mm x 160mm x 22mm
• Gewicht: 549g
• ISBN-13: 9783319499673
• ISBN-10: 331949967X
• Artikelnr.: 46608484

Inhaltsangabe

Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease.- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease.- Clinical features of LRRK2 carriers with Parkinson's disease.- Part II: Fundamentals of LRRK2 Biology.- LRRK2 phosphorylation.- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity.- LRRK2 and autophagy.- Molecular insights and functional implication of LRRK2 dimerization.- LRRK2 and the immune system.- Regulation of LRRK2 by phosphatases.- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options.- Animal models of LRRK2-associated Parkinson's disease.- LRRK2 and the "LRRKtosome" at the crossroads of programmed cell death: Clues from RIP kinase relatives.- Interaction of LRRK2 and -synuclein in Parkinson's disease.- Mechanisms of mutant LRRK2 neurodegeneration.- Small molecule inhibitors of LRRK2.

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Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson’s Disease.- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson’s disease.- Clinical features of LRRK2 carriers with Parkinson’s disease.- Part II: Fundamentals of LRRK2 Biology.- LRRK2 phosphorylation.- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity.- LRRK2 and autophagy.- Molecular insights and functional implication of LRRK2 dimerization.- LRRK2 and the immune system.- Regulation of LRRK2 by phosphatases.- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options.- Animal models of LRRK2-associated Parkinson’s disease.- LRRK2 and the “LRRKtosome” at the crossroads of programmed cell death: Clues from RIP kinase relatives.- Interaction of LRRK2 and α-synuclein in Parkinson’s disease.- Mechanisms of mutant LRRK2 neurodegeneration.- Small molecule inhibitors of LRRK2.