The role of Strategic Information Systems Planning (SISP) in healthcare necessitates a formal process of defining and updating the Information Systems Strategy (ISS). This book presents a process- and practiced-based approach to SISP at a pharmaceutical organization in Nigeria. We describe a five-phased sequential COBIT 5(Control Objectives for IT and Related Technologies)-based process and introduced various COBIT 5 tools and approaches. The process was informed by findings from a structured approach to the review of the SISP process. Process concerns identified in six dimensions called for the application of a good practice framework. COBIT 5 has been applied in the healthcare and related industry in many areas but has not found application in SISP. The application of COBIT 5 in SISP in an indigenous pharmaceutical organization would be beneficial to other pharmaceutical organizations engaging in similar efforts in the future. Such application has implications for both researchers and practitioners.