The more sophisticated and wide-ranging cyber-attacks present new threats to governments, critical infrastructures, and businesses across the world. National interest and public safety demand these dynamic hazards be understood for safeguarding. Cyber threats include APTs, ransomware, and cyber espionage. The threats touch on economic stability, resilient infrastructure, military operations, and personal privacy, which put national security at risk. Despite the growing threat environment, the landscape of detecting, analyzing, and responding to cybersecurity threats has been changing through artificial intelligence. AI-based solutions detect abnormalities, trends, and threats swiftly and effectively in terms of security through state-of-the-art algorithms, machine learning, and predictive analysis. Soon, AI is predicted to aid cybersecurity experts in attack prediction, defense, and enhancing national cyber resilience. This book reflects on AI-led cybersecurity solutions and supports persistent research, investment, and collaboration on the front to tackle new cyber threats.