The role of factors outside the province of the physical and biological sciences in the onset of illness has long been a source of speculation. While early efforts in psychosomatic medicine focused on the relationship between mental states and illness, the effects of personal status and social circumstances on physical health are only now receiving the attention they merit. By integrating current theory, methodology, and research, this ground-breaking volume advances the study of life events and disease to a new stage. George Brown and Tirril Harris are ideal editors for such an undertaking. George Brown has long been known for his path-breaking work on intensive clinical assessment and designing measures that capture the real complexity of social situations, assigned meanings, and personal response to crisis. He brought to light the importance of expressed emotion, ' the differential role of life events in schizophrenia and depression, and most recently, produced a seminal work on the social etiology of depression with Tirril Harris. As David Mechanic notes in his Foreword, the defining characteristics of these efforts, which are also reflected in this volume are a sensitivity to clinical material and capitalizing on serendipity; self-consciousness about methods and methodological advances; and focus on theory with careful efforts to specify intervening processes and the links between macro events and personal meanings.' Along with their collaborators, these eminent editors bring together an impressive range of theoretical thought and empirical study organized around the Life Events and Difficulties Schedule (LEDS). Their examination of the origins of life events anddifficulties and the notion of conveyor belts' to continuing adversity capture the immutable uncertainties of life and help to link concerns with life events and disease to larger issues of human development. The authors' innovative approach to establishing the relationship betwe