Linker Strategies in Solid-Phase Organic Synthesis

Herausgegeben von Scott, Peter

• Gebundenes Buch

Produktbeschreibung

Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include: * the principles of solid phase organic synthesis * electrophile and nucleophile cleavable linker units * cyclative cleavage as a solid phase strategy * photocleavable linker units * safety-catch linker units * enzyme cleavable linker units * T1 and T2 -versatile triazene linker groups * hydrazone linker units * benzotriazole linker units * phosphorus linker units * sulfur linker units * selenium and tellurium linker units * sulfur, oxygen and selenium linker units cleaved by radical processes * silicon and germanium linker units * boron and stannane linker units * bismuth linker units * transition metal carbonyl linker units * linkers releasing olefins or cycloolefins by ring-closing metathesis * fluorous linker units * solid-phase radiochemistry The book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis. Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.

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Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 706
• Erscheinungstermin: 1. Dezember 2009
• Englisch
• Abmessung: 253mm x 199mm x 43mm
• Gewicht: 1486g
• ISBN-13: 9780470511169
• ISBN-10: 0470511168
• Artikelnr.: 27139711

Autorenporträt

Dr Peter J. H. Scott, Department of Radiology, University of Michigan, Ann Arbor, USA Dr. Peter Scott has worked at Siemens Molecular Imaging and Biomarker Research where he was head of radiochemistry at the LA Tech Center and involved in the design and synthesis of novel radiopharmaceuticals for use in PET imaging. In April 2009 Dr. Scott joined the University of Michigan in the Department of Radiology where his research interests are developing novel tracers and technology for PET imaging, including solid phase radiochemistry.

Inhaltsangabe

Foreword.
Preface.
List of Contributors.
About the Editor.
Abbreviations.
I: INTRODUCTION.
Chapter 1: General Introduction (Scott L. Dax).
1.1 Introduction, Background and Pivotal Discoveries.
1.2 Fundamentals of Conducting Solid-Phase Organic Chemistry.
1.3 Concluding Comments.
1.4 Personal Perspective and Testimony: Solid-phase Mannich Chemistry.
1.5 References.
II: TRADITIONAL LINKER UNITS FOR SOLID-PHASE ORGANIC SYNTHESIS.
Chapter 2: Electrophile Cleavable Linker Units (Michio Kuruso).
2.1 Introduction.
2.2 Resins for use with Electrophilic Linkers.
2.3 Electrophile Cleavable Linkers.
2.4 Conclusion.
References.
Chapter 3: Nucleophile Cleavable Linker Units (Andrea Porcheddu and
Giampaolo Giacomelli).
3.1 Introduction.
3.2 Linker Units.
3.3 Nucleophilic Labile Linker Units.
3.4 Conclusion.
References.
Chapter 4: Cyclative Cleavage as a Solid-Phase Strategy (A. Ganesan).
4.1 Introduction.
4.2 C-N bond formation.
4.3 C-O bond formation.
4.4 C-C bond formation.
4.5 Conclusion.
References.
Chapter 5: Photolabile Linker Units (Christian Bochet and Sébastien
Mercier).
5.1 Introduction.
5.2 Linkers Based on the Ortho-Nitrobenzyloxy Function.
5.3 Linkers Based on the Ortho-Nitrobenzylamino Function.
5.4 Linkers Based on the ¿-Substituted Ortho-Nitrobenzyl Group.
5.5 Linkers Based on the Ortho-Nitroveratryl Group.
5.6 Linkers Based on the Phenacyl Group.
5.7 Linkers Based on the Para-Methoxyphenacyl Group.
5.8 Linkers Based on the Benzoin Group.
5.9 Linkers Based on the Pivaloyl Group.
5.10 Traceless Linkers.
5.11 Other Types of Photolabile Linker Units.
5.12 Conclusion.
References.
Chapter 6: Safety-Catch Linker Units (Sylvain Lebreton and Marcel Pátek).
6.1 Introduction.
6.2 Activation of a carbonyl group by the inductive effect (I-) of an
adjacent substituent.
6.3 Activation by the mesomeric effect (M-) of the X-Y=Z moiety adjacent to
a carbonyl group.
6.4 Activation by the positive mesomeric effect (M+) of the -X-Y=Z moiety
adjacent to a N-acyl or O-alkyl group.
6.5 Aromatic SNAr substitution.
6.6 Fragmentation by ß-elimination.
6.7 Safety-catch linker for release in aqueous buffers.
6.8 Photochemical activation.
6.9 Miscellaneous safety-catch linkers.
6.10 Conclusion.
6.11 References.
Chapter 7: Enzyme Cleavable Linker Units (Mallesham Bejugam and Sabine L.
Flitsch).
7.1 Introduction.
7.2 Enzyme Cleavable Linker Units.
7.3 Conclusion.
References.
III: MULTIFUNCTIONAL LINKER UNITS FOR DIVERSITY-ORIENTED SYNTHESIS.
Chapter 8: An Introduction to Diversity-Oriented Synthesis (Richard J.
Spandl, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and
David R. Spring).
8.1 Introduction.
8.2 Exploring Chemical Space.
8.3 Sources of Skeletally Diverse Small Molecules.
8.4 Enriching Chemical Space Using DOS.
8.5 The Subjective Nature of 'Diversity'.
8.6 Differing Strategies Towards Similar Goals.
8.7 Generating Skeletal Diversity.
8.8 DOS and Solid-Phase Organic Synthesis.
8.9 Conclusion.
References.
Chapter 9: T1 and T2 - Versatile Triazene Linker Groups (Kerstin Knepper
and Robert E. Ziegert).
9.1 Introduction.
9.2 The T1 Linker.
9.3 The T2 Linker Units.
9.4 Miscellaneous Triazene Linkers.
9.5 Conclusion.
9.6 References.
Chapter 10: Hydrazone Linker Units (Ryszard Lazny).
10.1 Introduction.
10.2 Hydrazone Linker Units.
10.3 Conclusion.
References.
Chapter 11: Benzotriazole Linker Units (Daniel K. Whelligan).
11.1 Introduction.
11.2 Syntheses of Polymer-Supported Benzotriazoles.
11.3 Polymer-Supported Benzotriazole Linked Reactions.
References.
Chapter 12: Diversity Cleavage Strategies from Phosphorus Linkers (Patrick
G. Steel and Tom M. Woods).
12.1 Introduction.
12.2 Diversity Cleavage through olefination reactions.
12.3 Diversity cleavage of enol phosphonates through palladium catalysed
cross-coupling reactions.
12.4 Oxidative diversity cleavage of cyanophosphoranes.
References.
Chapter 13: Sulfur Linker Units (Peter J. H. Scott).
13.1 Introduction.
13.2 Sulfide Linker Units.
13.3 Sulfonium Linker Units.
13.4 Sulfoxide Linker Units.
13.5 Sulfone Linker Units.
13.6 Sulfonate Ester Linker Units.
13.7 Sulfamate Linker Units.
13.8 Thioester Linker Units.
13.9 Conclusions.
References.
Chapter 14: Selenium- and Tellurium-Based Linker Units (Tracy Yuen Sze But
and Patrick H. Toy).
14.1 Introduction.
14.2 Selenium- and Tellurium-Based Linker Group Reagents and Their
Syntheses.
14.3 Selenium-Based Linker Group Attachment Methods.
14.4 Selenium-Based Linker Group Cleavage Methods.
14.5 Conclusions.
References.
Chapter 15: Linker Units Cleaved by Radical Processes: Cleavage of
Carbon-Sulfur, -Selenium, -Tellurium, -Oxygen, -Nitrogen and -Carbon
Linkers (Giuditta Guazzelli, Marc Miller and David J. Procter).
15.1 Introduction.
15.2 Linkers cleaved using tin hydride, alkyltin and silicon hydride
reagents.
15.3 Linkers cleaved by oxidative electron-transfer.
15.4 Linkers cleaved by reductive electron-transfer.
15.5 Radical processes that indirectly trigger linker cleavage.
15.6 Conclusions.
References.
Chapter 16: Silicon and Germanium Linker Units (Alan C. Spivey and
Christopher M. Diaper).
16.1Introduction.
16.2 Silicon-based Linkers.
16.3 Germanium-based Linkers.
16.4 Conclusions.
References.
Chapter 17: Boron and Stannane Linker Units (Peter J.H. Scott).
17.1 Introduction.
17.2 Organostannane Linker Units.
17.3 Organoboron Linker Units.
17.4 Conclusion.
References.
Chapter 18: Bismuth Linker Units (Peter J.H Scott).
18.1 Introduction.
18.2 Bismuth Linker Units.
18.3 Conclusion.
References.
Chapter 19: Transition Metal Carbonyl Linker Units (Susan E. Gibson and
Amol A. Walke).
19.1 Introduction.
19.2 Chromium carbonyl linker units.
19.3 Cobalt carbonyl linker units.
19.4 Manganese carbonyl linker units.
19.5 Conclusion.
References.
Chapter 20: Linkers Releasing Olefins or Cycloolefins by Ring Closing
Metathesis (Jan H. van Maarseveen).
20.1 Introduction.
20.2 Cycloolefins via method I.
20.3 Terminal olefins via route II.
20.4 Terminal and internal olefins via route III.
20.5 Conclusion.
References.
PART 4: ALTERNATIVE LINKER STRATEGIES.
Chapter 21: Fluorous Linker Units (Wei Zhang).
21.1 Introduction.
21.2 Fluorous linkers for synthesis of small molecules.
21.3 Fluorous linkers for synthesis of biomolecules.
21.4 Other applications of fluorous linkers.
21.5 Conclusion.
References.
Chapter 22: Solid-Phase Radiochemistry (Brian G. Hockley, Peter J. H. Scott
and Michael R. Kilbourn).
22.1 Introduction.
22.2 Solid-Phase Surrogates in Radiochemistry.
22.3 Solid-Phase Radiochemistry.
22.4 Conclusions and Perspectives.
References.
PART 5: LINKER SELECTION TABLES.
Chapter 23: Linker Selection Tables (Peter J.H. Scott).
23.1 Introduction.
23.2 Linkers for Alcohols, Phenols and Diols.
23.3 Linkers for Carboxylic Acids, Esters and Related Compounds.
23.4 Linkers for Aldehydes, Ketones and Related Carbonyl Compounds.
23.5 Linkers for Amides, Ureas and Related Compounds.
23.6 Linkers for Amines.
23.7 Linkers Thiols, Thioethers and Disulfides.
23.8 Linkers for Sugars.
23.9 Linkers Liberating Alkyl Groups.
23.10 Linkers for Alkenes, Alkynes and Related Compounds.
23.11 Linkers for Aryl Compounds.
Index.

Rezensionen

"It is without a doubt an invaluable addition to any university or corporate library serving organic and biochemical researchers." (CHOICE, September 2010)
"This book is a useful complement to literature reviews as well as other SPOS books. It will be a valuable resource for university libraries and an excellent first source for practitioners of solid-phase organic synthesis." (JACS, 2010)