During the past decade we have witnessed a vast expansion in our knowl edge of lipid metabolism, especially for mammalian tissues. One obvious conclusion arising from these studies is that no single overall scheme of lipid metabolism can be classed as distinctly characteristic of all mamma lian organs. Although certain synthetic and degradative lipid pathways are similar in a variety of organs, I have been impressed by the notable exceptions. I was motivated to organize this work on Lipid Metabolism in Mammals because of the lack of a single reference source containing a comparative organ…mehr
During the past decade we have witnessed a vast expansion in our knowl edge of lipid metabolism, especially for mammalian tissues. One obvious conclusion arising from these studies is that no single overall scheme of lipid metabolism can be classed as distinctly characteristic of all mamma lian organs. Although certain synthetic and degradative lipid pathways are similar in a variety of organs, I have been impressed by the notable exceptions. I was motivated to organize this work on Lipid Metabolism in Mammals because of the lack of a single reference source containing a comparative organ approach to lipid metabolism in mammals that empha sizes the uniqueness of pathways in the various organs of the body. Because of the escalation in lipid research, I also feel strongly that there is an urgent need for an updated concise account of this field. The group of authors for the chapters in the two volumes of Lipid Metabolism in Mammals were selected for their expertise and personal experience with the lipid metabolism of the organs or blood constituents that are the subjects of the chapters. Sufficient leeway has been given each author to approach the subject matter from a personal viewpoint. How ever, the overall direction of each chapter has been slanted to emphasize the similarities and differences in lipid metabolism among organ systems. The introductory chapter on general pathways provides a convenient refer ence to illustrations of specific reaction sequences that are well established of organs.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Lung.- I. Introduction.- II. Fatty Acid Metabolism.- III. Complex Lipid Metabolism.- IV. Cellular Sites of Lipid Metabolism.- V. Developmental and Control Aspects.- Kidney.- I. Introduction.- II. Free Fatty Acids.- III. Phospholipids.- IV. Cholesterol.- V. Prostaglandins.- VI. Sphingolipids.- VII. Vitamin D3.- Gonadal Tissue.- I. Introduction.- II. Major Lipid and Fatty Acid Composition.- III. Biosynthesis and Metabolism of Major Lipid Classes and of Fatty Acids.- IV. Other Lipids.- V. Lipids and Lipid Metabolism in Spermatozoa.- VI. Role of Lipids in Reproduction.- VII. Concluding Remarks.- Mammary Glands.- I. Introduction.- II. Fatty Acid Synthesis and Oxidation in Lactating Mammary Glands.- III. Triacylglycerol and Phospholipid Synthesis in Lactating Mammary Glands.- IV. Hormonal Control of Milk Fat Synthesis.- The Eye.- I. Introduction.- II. Ocular Anatomy.- III. Lens.- IV. Retina and Optic Nerve.- V. Cornea and Sclera.- VI. Iris, Ciliary Body, and Choroid.- VII. Vitreous Body, Aqueous Humor, and Tear Fluid.- Skeletal Muscle.- I. Lipid Composition of Mammalian Skeletal Muscle.- II. Lipid Metabolism.- III. Lipid Metabolism in Muscular Dystrophy.- IV. Role of Phospholipids in Sarcoplasmic Reticulum.- V. Energy Factors in Muscular Exercise.- Skin.- I. Structure of Skin.- II. Sampling Skin Lipids.- III. Composition of Skin Lipids.- IV. Factors Affecting Rate of Sebum Production.- V. Factors Affecting the Composition of Skin Surface Lipids.- VI. Lipogenesis in Skin.- VII. Sterol Metabolism in Skin.- VIII. Biochemistry of Specialized Sebaceous Structures.- Calcified Tissues.- I. Introduction.- II. Anatomy and Physiology of Teeth and Bone.- III. Histochemical Observations on Lipids of Calcified Tissues.- IV. Lipid Extraction Procedures for Calcified Tissues.- V. Quantitative and Qualitative Analysis of Mineralized Tissues.- VI. In Vitro Lipid Metabolism by Bone and Bone Cell Cultures.- VII. The Role of Lipids in Calcification.- VIII. Summary.- Cancer Cells.- I. Introduction.- II. Fatty Acids.- III. Fatty Alcohols.- IV. Glycerolipids.- V. Glycolipids.- VI. Cholesterol.- Harderian Gland.- I. Introduction.- II. Lipid Composition.- III. Lipid Metabolism.- IV. Epilogue.- Cultured Cells.- I. Introduction.- II. Cellular Lipid Nutrition.- III. Factors Influencing Cell Cholesterol Uptake.- IV. Feedback Regulation of Cholesterol Biosynthesis.- V. Genetic Abnormalities in Regulation of Cholesterol Synthesis.- VI. Feedback Control of Acetate Incorporation into Cell Lipids.- VII. Defective Control of Lipid Metabolism in Tumors and Transformed Cells.- VIII. Essential Fatty Acid Requirements and Metabolism.- IX. Summary and Conclusions.- Lipid Changes in Membranes during Growth and Development.- I. Introduction.- II. The Cell Cycle.- III. Stimulation of Quiescent Cells.- IV. Embryonic Development.- V. Other Developmental Situations.- VI. Abnormal Development.- VII. Conclusions.
Lung.- I. Introduction.- II. Fatty Acid Metabolism.- III. Complex Lipid Metabolism.- IV. Cellular Sites of Lipid Metabolism.- V. Developmental and Control Aspects.- Kidney.- I. Introduction.- II. Free Fatty Acids.- III. Phospholipids.- IV. Cholesterol.- V. Prostaglandins.- VI. Sphingolipids.- VII. Vitamin D3.- Gonadal Tissue.- I. Introduction.- II. Major Lipid and Fatty Acid Composition.- III. Biosynthesis and Metabolism of Major Lipid Classes and of Fatty Acids.- IV. Other Lipids.- V. Lipids and Lipid Metabolism in Spermatozoa.- VI. Role of Lipids in Reproduction.- VII. Concluding Remarks.- Mammary Glands.- I. Introduction.- II. Fatty Acid Synthesis and Oxidation in Lactating Mammary Glands.- III. Triacylglycerol and Phospholipid Synthesis in Lactating Mammary Glands.- IV. Hormonal Control of Milk Fat Synthesis.- The Eye.- I. Introduction.- II. Ocular Anatomy.- III. Lens.- IV. Retina and Optic Nerve.- V. Cornea and Sclera.- VI. Iris, Ciliary Body, and Choroid.- VII. Vitreous Body, Aqueous Humor, and Tear Fluid.- Skeletal Muscle.- I. Lipid Composition of Mammalian Skeletal Muscle.- II. Lipid Metabolism.- III. Lipid Metabolism in Muscular Dystrophy.- IV. Role of Phospholipids in Sarcoplasmic Reticulum.- V. Energy Factors in Muscular Exercise.- Skin.- I. Structure of Skin.- II. Sampling Skin Lipids.- III. Composition of Skin Lipids.- IV. Factors Affecting Rate of Sebum Production.- V. Factors Affecting the Composition of Skin Surface Lipids.- VI. Lipogenesis in Skin.- VII. Sterol Metabolism in Skin.- VIII. Biochemistry of Specialized Sebaceous Structures.- Calcified Tissues.- I. Introduction.- II. Anatomy and Physiology of Teeth and Bone.- III. Histochemical Observations on Lipids of Calcified Tissues.- IV. Lipid Extraction Procedures for Calcified Tissues.- V. Quantitative and Qualitative Analysis of Mineralized Tissues.- VI. In Vitro Lipid Metabolism by Bone and Bone Cell Cultures.- VII. The Role of Lipids in Calcification.- VIII. Summary.- Cancer Cells.- I. Introduction.- II. Fatty Acids.- III. Fatty Alcohols.- IV. Glycerolipids.- V. Glycolipids.- VI. Cholesterol.- Harderian Gland.- I. Introduction.- II. Lipid Composition.- III. Lipid Metabolism.- IV. Epilogue.- Cultured Cells.- I. Introduction.- II. Cellular Lipid Nutrition.- III. Factors Influencing Cell Cholesterol Uptake.- IV. Feedback Regulation of Cholesterol Biosynthesis.- V. Genetic Abnormalities in Regulation of Cholesterol Synthesis.- VI. Feedback Control of Acetate Incorporation into Cell Lipids.- VII. Defective Control of Lipid Metabolism in Tumors and Transformed Cells.- VIII. Essential Fatty Acid Requirements and Metabolism.- IX. Summary and Conclusions.- Lipid Changes in Membranes during Growth and Development.- I. Introduction.- II. The Cell Cycle.- III. Stimulation of Quiescent Cells.- IV. Embryonic Development.- V. Other Developmental Situations.- VI. Abnormal Development.- VII. Conclusions.
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