Carcinoma breast is one of the common killer disease in women worldwide, researches are working on this topic. Multiple factors are known to be responsible for it. Research work should be continued to reduce the occurrence of this disease and we should look for the control of disease. Overweight, Obesity, imbalance of lipid profile, malnutrition, familial inheritance and many others are the responsible factors. We as a clinicians have important role in combating this and many other deadly diseases.