Our approach and analysis of El Registro Yucateco. Periódico redactado por una sociedad de amigos (1845-49) published, at first, in the city of Mérida and, later, in the city of Campeche, Yucatán Peninsula (Mexico) allows us to evidence a series of dynamics to which the nascent Mexican literature was subject at the time of its publication. The importance of El Registro Yucateco lies in the fact that it is one of the few literary newspapers that managed to complete such an extensive series (four volumes of approximately 500 pages each), at a very early stage of the development of national literature; as well as for being part of a tradition of literary journalism. In addition to the above, the novel Un año en el hospital de San Lázaro (A year in the hospital of San Lázaro ) appears in it, which becomes the main axis that, starting from a leprosy patient with strong ties to piracy, intertwines the multiple discourses present in El Registro Yucateco to make a proposal for a nation.