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Local anesthetics are agents widely used to perform central and peripheral nerve blocks, infiltrative anesthesia, intravenous regional anesthesia and in continuous intravenous infusion for analgesic or antiarrhythmic purposes.In the course of this book we will refresh our knowledge about pharmacokinetics and pharmacodynamics of local anesthetics, we will delve into the signs of local anesthetic systemic toxicity system by system and we will focus on the specific treatment of it.