Gingival and periodontal diseases in their miscellaneous forms have afflicted mankind since the dawn of history. The primary role of bacteria in the etiology of periodontal diseases is indisputable. Various treatment modalities have been modified for the successful clinical management of these diseases. A new approach using local drug delivery system containing antibiotic or antiseptic drugs has been introduced. This system is designed to target periodontal infections depending upon its ability to deliver the antimicrobial agents to the base of pocket, at a bacteriostatic or bactericidal concentration and also facilitates retention of the medicament long enough to ensure an efficacious result. The aim of this book is to review the current status of local drug delivery, their usefulness, indications, contraindications, various drug delivery devices as well as the advancement of these systems in the treatment of periodontitis.