Eran Meshorer

Long-lasting stress-induced changes in neuronal alternative splicing

Stress-induced molecular changes in the mammalian brain

• Broschiertes Buch

Produktbeschreibung

Ample information suggests multileveled relationships
between long-term psychological stress responses and
alternative splicing the process which yields
different mRNAs from the same gene. However, the
nature of these relationships remains unclear. Eran
Meshorer studied the stress-induced changes in
alternative splicing at Hermona Soreq s lab and shed
light on the molecular pathways that lead to such
responses. Meshorer focused on a particular mRNA -
acetylcholinesterase (AChE), which is
neuronally-expressed, stress-responsive, and yields
alternatively spliced products, thus serving as an
adequate model for this purpose. The book begins with
an introduction covering the general areas of stress
responses, their long-term consequences, the
mechanism of splicing and alternative splicing,
neuritic translocation of mRNAs and highlights the
AChE gene and its protein products as putative
mediators of such long-term consequences. The results
section depicts 3 works describing 3 and 5
alternative splicing of AChE and a potential mediator
of the stress-induced responses. Finally, the book
ends with a discussion on the consequences of such
responses, linking stress responses with aging.

Produktdetails

• Verlag: VDM Verlag Dr. Müller
• Seitenzahl: 100
• Englisch
• Gewicht: 150g
• ISBN-13: 9783639147162
• ISBN-10: 3639147162
• Artikelnr.: 26220933

Autorenporträt

Eran Meshorer obtained his PhD from The Hebrew University of
Jerusalem, studying long-term stress responses in the brain. He
did his postdoctoral studies at the NIH, studying chromatin in
embryonic stem cells. The work here was published in Science,
JBC, FASEB J and Mol Psychiatry, the latter receiving the Lilly
Award for the best paper of 2005.