Lyophilized Polymer Matrices for Improved Transdermal Drug Delivery
Balkrishna Dubey
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Lyophilized Polymer Matrices for Improved Transdermal Drug Delivery

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Transdermal matrices when subjected to dry in air at room temperature usually contain uneven drug distribution due to migration of drug molecules during moisture evaporation.Such matrices do not show uniform release of the drug. The technique of lyophilization can successfully be used for the preparation of polymer matrices which minimize the possibilities of uneven drug distribution in matrix. The uniformity in drug distribution pattern also proved to be useful in reproducing the release kinetics and the channelised drug matrix resulted from the lyophilization further adds to the release rate...