Broschiertes Buch

Lysine Biosynthesis in Plants

Characterization of an LL-Diaminopimelate Aminotansferase that Defines a Novel Variant of the Lysine Anabolic Pathways

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The pathway by which plants synthesize the essential amino acid lysine was not completely clear. The goal of this work was to identify the genes that make up this essential pathway from plants. This led to the discovery of a novel enzyme L,L-diaminopimelate aminotransferase that is able to bridge the metabolic gap between two compounds that is necessary for lysine biosynthesis. This is important because attempts to produce plants that over produce lysine have been done without the knowledge of how plants synthesize this amino acid.

Andre Hudson§Curriculum VitaAndre O. HudsonEducation2006-presentPost-doctoral associate, Rutgers University, The State University New Brunswick, NJ.2000-2006Ph.D. Plant Biology, Rutgers, The State University of New Jersey,New Brunswick, NJ.1996-2000B.S. Biology, Virginia Union University, Richmond, VA.Awards2003-present National Institutes of Health (N.I.H) Bridges Scholar 2003-present N.I.H Pre-doctoral Fellowship (GM069264)2000-2002 N.I.H. training grant (GM55145)1999 MARC/AIM Scholar (Purdue University)1998-2000 MARC U_STAR Scholar Virginia Union University (N.I.H) (GM08503)1996-2000 Dean's Honor list (Virginia Union University)1996-2000Academic Scholarship (Virginia Union University)PublicationsMartin M, Saladores P, Lambert E, Hudson AO, Lesutek T (2007). Localization of members of the ?-glutamyl transpepdidase family identifies sites of glutathione and glutathione S-conjugate hydrolysis. Plant Physiol (144) 1742-1752.McCoy A,Adams N, Hudson AO, Gilvarg C, Leustek T, Maurelli A (2006) Chlamydia trachomatis CT390 is a transkingdom LL-diaminopimelate aminotransferase variant of the meso-diaminopimelate/lysine biosynthetic pathway. PNAS 103 No. 47 17909-17914.Hudson, AO, Singh BK, Leustek T and Gilvarg C. (2006) An L,L- diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants. Plant Physiology. 140: 292-301.Hudson, AO, Bless, C. Macedo, P. Chatterjee SP. Singh, BK. Gilvarg, C. Leustek, T. (2005). Biosynthesis of lysine in plants: evidence for a variant of the known bacterial pathways. Biochemica et Biophysica Acta. 1721:27-36Lee, M., Martin M., Hudson A., Lee, J., Muhitch, M., Leustek, T. (2005)Methionine and threonine synthesis are limited by homoserine availability and not the activity of homoserine kinase in Arabidopsis thaliana. The Plant Journal. 41:685-696Morgan, CA., Hudson, A., Konopka A, Nakatsu CH. (2002) Analyses of microbial activity in biomass-recycle reactors using denaturing gradient gel electrophoresis of 16S rDNA and 16S rRNA PCR products. Can. J. Microbiol. 48: 333-341